diff --git a/crypto_generichash.js b/crypto_generichash.js
index 36b9111..2d7a3a7 100644
--- a/crypto_generichash.js
+++ b/crypto_generichash.js
@@ -1,5 +1,7 @@
 var blake2b = require('blake2b')
 
+if (new Uint16Array([1])[0] !== 1) throw new Error('Big endian architecture is not supported.')
+
 module.exports.crypto_generichash_PRIMITIVE = 'blake2b'
 module.exports.crypto_generichash_BYTES_MIN = blake2b.BYTES_MIN
 module.exports.crypto_generichash_BYTES_MAX = blake2b.BYTES_MAX
diff --git a/crypto_shorthash.js b/crypto_shorthash.js
index b1b8378..a617e4a 100644
--- a/crypto_shorthash.js
+++ b/crypto_shorthash.js
@@ -1,5 +1,7 @@
 var siphash = require('siphash24')
 
+if (new Uint16Array([1])[0] !== 1) throw new Error('Big endian architecture is not supported.')
+
 exports.crypto_shorthash_PRIMITIVE = 'siphash24'
 exports.crypto_shorthash_BYTES = siphash.BYTES
 exports.crypto_shorthash_KEYBYTES = siphash.KEYBYTES
diff --git a/crypto_stream.js b/crypto_stream.js
index 303e40d..a106a72 100644
--- a/crypto_stream.js
+++ b/crypto_stream.js
@@ -1,5 +1,7 @@
 var xsalsa20 = require('xsalsa20')
 
+if (new Uint16Array([1])[0] !== 1) throw new Error('Big endian architecture is not supported.')
+
 exports.crypto_stream_KEYBYTES = 32
 exports.crypto_stream_NONCEBYTES = 24
 exports.crypto_stream_PRIMITIVE = 'xsalsa20'
diff --git a/crypto_stream_chacha20.js b/crypto_stream_chacha20.js
index 2832d3a..bdcfef2 100644
--- a/crypto_stream_chacha20.js
+++ b/crypto_stream_chacha20.js
@@ -1,6 +1,8 @@
 const assert = require('nanoassert')
 const Chacha20 = require('chacha20-universal')
 
+if (new Uint16Array([1])[0] !== 1) throw new Error('Big endian architecture is not supported.')
+
 exports.crypto_stream_chacha20_KEYBYTES = 32
 exports.crypto_stream_chacha20_NONCEBYTES = 8
 exports.crypto_stream_chacha20_MESSAGEBYTES_MAX = Number.MAX_SAFE_INTEGER
diff --git a/ed25519.js b/ed25519.js
index 9553eb0..2e92b6f 100644
--- a/ed25519.js
+++ b/ed25519.js
@@ -1,3 +1,5 @@
+if (new Uint16Array([1])[0] !== 1) throw new Error('Big endian architecture is not supported.')
+
 var gf = function(init) {
   var i, r = new Float64Array(16);
   if (init) for (i = 0; i < init.length; i++) r[i] = init[i];
diff --git a/poly1305.js b/poly1305.js
index 34e5ef6..96af7f1 100644
--- a/poly1305.js
+++ b/poly1305.js
@@ -3,6 +3,8 @@
 * https://github.com/floodyberry/poly1305-donna
 */
 
+if (new Uint16Array([1])[0] !== 1) throw new Error('Big endian architecture is not supported.')
+
 var poly1305 = function(key) {
   this.buffer = new Uint8Array(16);
   this.r = new Uint16Array(10);