diff --git a/common/eth2/src/lighthouse_vc/http_client.rs b/common/eth2/src/lighthouse_vc/http_client.rs
index b2d53c5e0..2e6756c63 100644
--- a/common/eth2/src/lighthouse_vc/http_client.rs
+++ b/common/eth2/src/lighthouse_vc/http_client.rs
@@ -226,11 +226,32 @@ impl ValidatorClientHttpClient {
         ok_or_error(response).await
     }
 
+    /// Perform a HTTP DELETE request, returning the `Response` for further processing.
+    async fn delete_response<U: IntoUrl>(&self, url: U) -> Result<Response, Error> {
+        let response = self
+            .client
+            .delete(url)
+            .headers(self.headers()?)
+            .send()
+            .await
+            .map_err(Error::from)?;
+        ok_or_error(response).await
+    }
+
     async fn get<T: DeserializeOwned, U: IntoUrl>(&self, url: U) -> Result<T, Error> {
         let response = self.get_response(url).await?;
         self.signed_json(response).await
     }
 
+    async fn delete<U: IntoUrl>(&self, url: U) -> Result<(), Error> {
+        let response = self.delete_response(url).await?;
+        if response.status().is_success() {
+            Ok(())
+        } else {
+            Err(Error::StatusCode(response.status()))
+        }
+    }
+
     async fn get_unsigned<T: DeserializeOwned, U: IntoUrl>(&self, url: U) -> Result<T, Error> {
         self.get_response(url)
             .await?
@@ -537,6 +558,18 @@ impl ValidatorClientHttpClient {
         Ok(url)
     }
 
+    fn make_graffiti_url(&self, pubkey: &PublicKeyBytes) -> Result<Url, Error> {
+        let mut url = self.server.full.clone();
+        url.path_segments_mut()
+            .map_err(|()| Error::InvalidUrl(self.server.clone()))?
+            .push("eth")
+            .push("v1")
+            .push("validator")
+            .push(&pubkey.to_string())
+            .push("graffiti");
+        Ok(url)
+    }
+
     fn make_gas_limit_url(&self, pubkey: &PublicKeyBytes) -> Result<Url, Error> {
         let mut url = self.server.full.clone();
         url.path_segments_mut()
@@ -684,6 +717,34 @@ impl ValidatorClientHttpClient {
 
         self.post(path, &()).await
     }
+
+    /// `GET /eth/v1/validator/{pubkey}/graffiti`
+    pub async fn get_graffiti(
+        &self,
+        pubkey: &PublicKeyBytes,
+    ) -> Result<GetGraffitiResponse, Error> {
+        let url = self.make_graffiti_url(pubkey)?;
+        self.get(url)
+            .await
+            .map(|generic: GenericResponse<GetGraffitiResponse>| generic.data)
+    }
+
+    /// `POST /eth/v1/validator/{pubkey}/graffiti`
+    pub async fn set_graffiti(
+        &self,
+        pubkey: &PublicKeyBytes,
+        graffiti: GraffitiString,
+    ) -> Result<(), Error> {
+        let url = self.make_graffiti_url(pubkey)?;
+        let set_graffiti_request = SetGraffitiRequest { graffiti };
+        self.post(url, &set_graffiti_request).await
+    }
+
+    /// `DELETE /eth/v1/validator/{pubkey}/graffiti`
+    pub async fn delete_graffiti(&self, pubkey: &PublicKeyBytes) -> Result<(), Error> {
+        let url = self.make_graffiti_url(pubkey)?;
+        self.delete(url).await
+    }
 }
 
 /// Returns `Ok(response)` if the response is a `200 OK` response or a
diff --git a/common/eth2/src/lighthouse_vc/std_types.rs b/common/eth2/src/lighthouse_vc/std_types.rs
index 33e2f764e..ab90d336f 100644
--- a/common/eth2/src/lighthouse_vc/std_types.rs
+++ b/common/eth2/src/lighthouse_vc/std_types.rs
@@ -1,7 +1,7 @@
 use account_utils::ZeroizeString;
 use eth2_keystore::Keystore;
 use serde::{Deserialize, Serialize};
-use types::{Address, PublicKeyBytes};
+use types::{Address, Graffiti, PublicKeyBytes};
 
 pub use slashing_protection::interchange::Interchange;
 
@@ -172,3 +172,9 @@ pub enum DeleteRemotekeyStatus {
 pub struct DeleteRemotekeysResponse {
     pub data: Vec<Status<DeleteRemotekeyStatus>>,
 }
+
+#[derive(Debug, Deserialize, Serialize)]
+pub struct GetGraffitiResponse {
+    pub pubkey: PublicKeyBytes,
+    pub graffiti: Graffiti,
+}
diff --git a/common/eth2/src/lighthouse_vc/types.rs b/common/eth2/src/lighthouse_vc/types.rs
index f1a91b4ef..230293f1b 100644
--- a/common/eth2/src/lighthouse_vc/types.rs
+++ b/common/eth2/src/lighthouse_vc/types.rs
@@ -168,3 +168,8 @@ pub struct SingleExportKeystoresResponse {
     #[serde(skip_serializing_if = "Option::is_none")]
     pub validating_keystore_password: Option<ZeroizeString>,
 }
+
+#[derive(Serialize, Deserialize, Debug)]
+pub struct SetGraffitiRequest {
+    pub graffiti: GraffitiString,
+}
diff --git a/validator_client/src/http_api/graffiti.rs b/validator_client/src/http_api/graffiti.rs
new file mode 100644
index 000000000..79d4fd61f
--- /dev/null
+++ b/validator_client/src/http_api/graffiti.rs
@@ -0,0 +1,80 @@
+use crate::validator_store::ValidatorStore;
+use bls::PublicKey;
+use slot_clock::SlotClock;
+use std::sync::Arc;
+use types::{graffiti::GraffitiString, EthSpec, Graffiti};
+
+pub fn get_graffiti<T: 'static + SlotClock + Clone, E: EthSpec>(
+    validator_pubkey: PublicKey,
+    validator_store: Arc<ValidatorStore<T, E>>,
+    graffiti_flag: Option<Graffiti>,
+) -> Result<Graffiti, warp::Rejection> {
+    let initialized_validators_rw_lock = validator_store.initialized_validators();
+    let initialized_validators = initialized_validators_rw_lock.read();
+    match initialized_validators.validator(&validator_pubkey.compress()) {
+        None => Err(warp_utils::reject::custom_not_found(
+            "The key was not found on the server".to_string(),
+        )),
+        Some(_) => {
+            let Some(graffiti) = initialized_validators.graffiti(&validator_pubkey.into()) else {
+                return graffiti_flag.ok_or(warp_utils::reject::custom_server_error(
+                    "No graffiti found, unable to return the process-wide default".to_string(),
+                ));
+            };
+            Ok(graffiti)
+        }
+    }
+}
+
+pub fn set_graffiti<T: 'static + SlotClock + Clone, E: EthSpec>(
+    validator_pubkey: PublicKey,
+    graffiti: GraffitiString,
+    validator_store: Arc<ValidatorStore<T, E>>,
+) -> Result<(), warp::Rejection> {
+    let initialized_validators_rw_lock = validator_store.initialized_validators();
+    let mut initialized_validators = initialized_validators_rw_lock.write();
+    match initialized_validators.validator(&validator_pubkey.compress()) {
+        None => Err(warp_utils::reject::custom_not_found(
+            "The key was not found on the server, nothing to update".to_string(),
+        )),
+        Some(initialized_validator) => {
+            if initialized_validator.get_graffiti() == Some(graffiti.clone().into()) {
+                Ok(())
+            } else {
+                initialized_validators
+                    .set_graffiti(&validator_pubkey, graffiti)
+                    .map_err(|_| {
+                        warp_utils::reject::custom_server_error(
+                            "A graffiti was found, but failed to be updated.".to_string(),
+                        )
+                    })
+            }
+        }
+    }
+}
+
+pub fn delete_graffiti<T: 'static + SlotClock + Clone, E: EthSpec>(
+    validator_pubkey: PublicKey,
+    validator_store: Arc<ValidatorStore<T, E>>,
+) -> Result<(), warp::Rejection> {
+    let initialized_validators_rw_lock = validator_store.initialized_validators();
+    let mut initialized_validators = initialized_validators_rw_lock.write();
+    match initialized_validators.validator(&validator_pubkey.compress()) {
+        None => Err(warp_utils::reject::custom_not_found(
+            "The key was not found on the server, nothing to delete".to_string(),
+        )),
+        Some(initialized_validator) => {
+            if initialized_validator.get_graffiti().is_none() {
+                Ok(())
+            } else {
+                initialized_validators
+                    .delete_graffiti(&validator_pubkey)
+                    .map_err(|_| {
+                        warp_utils::reject::custom_server_error(
+                            "A graffiti was found, but failed to be removed.".to_string(),
+                        )
+                    })
+            }
+        }
+    }
+}
diff --git a/validator_client/src/http_api/mod.rs b/validator_client/src/http_api/mod.rs
index 669edc671..c65beb739 100644
--- a/validator_client/src/http_api/mod.rs
+++ b/validator_client/src/http_api/mod.rs
@@ -1,12 +1,15 @@
 mod api_secret;
 mod create_signed_voluntary_exit;
 mod create_validator;
+mod graffiti;
 mod keystores;
 mod remotekeys;
 mod tests;
 
 pub mod test_utils;
 
+use crate::http_api::graffiti::{delete_graffiti, get_graffiti, set_graffiti};
+
 use crate::http_api::create_signed_voluntary_exit::create_signed_voluntary_exit;
 use crate::{determine_graffiti, GraffitiFile, ValidatorStore};
 use account_utils::{
@@ -19,7 +22,10 @@ use create_validator::{
 };
 use eth2::lighthouse_vc::{
     std_types::{AuthResponse, GetFeeRecipientResponse, GetGasLimitResponse},
-    types::{self as api_types, GenericResponse, Graffiti, PublicKey, PublicKeyBytes},
+    types::{
+        self as api_types, GenericResponse, GetGraffitiResponse, Graffiti, PublicKey,
+        PublicKeyBytes, SetGraffitiRequest,
+    },
 };
 use lighthouse_version::version_with_platform;
 use logging::SSELoggingComponents;
@@ -653,7 +659,7 @@ pub fn serve<T: 'static + SlotClock + Clone, E: EthSpec>(
         .and(warp::path::end())
         .and(warp::body::json())
         .and(validator_store_filter.clone())
-        .and(graffiti_file_filter)
+        .and(graffiti_file_filter.clone())
         .and(signer.clone())
         .and(task_executor_filter.clone())
         .and_then(
@@ -1028,6 +1034,86 @@ pub fn serve<T: 'static + SlotClock + Clone, E: EthSpec>(
             },
         );
 
+    // GET /eth/v1/validator/{pubkey}/graffiti
+    let get_graffiti = eth_v1
+        .and(warp::path("validator"))
+        .and(warp::path::param::<PublicKey>())
+        .and(warp::path("graffiti"))
+        .and(warp::path::end())
+        .and(validator_store_filter.clone())
+        .and(graffiti_flag_filter)
+        .and(signer.clone())
+        .and_then(
+            |pubkey: PublicKey,
+             validator_store: Arc<ValidatorStore<T, E>>,
+             graffiti_flag: Option<Graffiti>,
+             signer| {
+                blocking_signed_json_task(signer, move || {
+                    let graffiti = get_graffiti(pubkey.clone(), validator_store, graffiti_flag)?;
+                    Ok(GenericResponse::from(GetGraffitiResponse {
+                        pubkey: pubkey.into(),
+                        graffiti,
+                    }))
+                })
+            },
+        );
+
+    // POST /eth/v1/validator/{pubkey}/graffiti
+    let post_graffiti = eth_v1
+        .and(warp::path("validator"))
+        .and(warp::path::param::<PublicKey>())
+        .and(warp::path("graffiti"))
+        .and(warp::body::json())
+        .and(warp::path::end())
+        .and(validator_store_filter.clone())
+        .and(graffiti_file_filter.clone())
+        .and(signer.clone())
+        .and_then(
+            |pubkey: PublicKey,
+             query: SetGraffitiRequest,
+             validator_store: Arc<ValidatorStore<T, E>>,
+             graffiti_file: Option<GraffitiFile>,
+             signer| {
+                blocking_signed_json_task(signer, move || {
+                    if graffiti_file.is_some() {
+                        return Err(warp_utils::reject::invalid_auth(
+                            "Unable to update graffiti as the \"--graffiti-file\" flag is set"
+                                .to_string(),
+                        ));
+                    }
+                    set_graffiti(pubkey.clone(), query.graffiti, validator_store)
+                })
+            },
+        )
+        .map(|reply| warp::reply::with_status(reply, warp::http::StatusCode::ACCEPTED));
+
+    // DELETE /eth/v1/validator/{pubkey}/graffiti
+    let delete_graffiti = eth_v1
+        .and(warp::path("validator"))
+        .and(warp::path::param::<PublicKey>())
+        .and(warp::path("graffiti"))
+        .and(warp::path::end())
+        .and(validator_store_filter.clone())
+        .and(graffiti_file_filter.clone())
+        .and(signer.clone())
+        .and_then(
+            |pubkey: PublicKey,
+             validator_store: Arc<ValidatorStore<T, E>>,
+             graffiti_file: Option<GraffitiFile>,
+             signer| {
+                blocking_signed_json_task(signer, move || {
+                    if graffiti_file.is_some() {
+                        return Err(warp_utils::reject::invalid_auth(
+                            "Unable to delete graffiti as the \"--graffiti-file\" flag is set"
+                                .to_string(),
+                        ));
+                    }
+                    delete_graffiti(pubkey.clone(), validator_store)
+                })
+            },
+        )
+        .map(|reply| warp::reply::with_status(reply, warp::http::StatusCode::NO_CONTENT));
+
     // GET /eth/v1/keystores
     let get_std_keystores = std_keystores
         .and(signer.clone())
@@ -1175,6 +1261,7 @@ pub fn serve<T: 'static + SlotClock + Clone, E: EthSpec>(
                         .or(get_lighthouse_ui_graffiti)
                         .or(get_fee_recipient)
                         .or(get_gas_limit)
+                        .or(get_graffiti)
                         .or(get_std_keystores)
                         .or(get_std_remotekeys)
                         .recover(warp_utils::reject::handle_rejection),
@@ -1189,6 +1276,7 @@ pub fn serve<T: 'static + SlotClock + Clone, E: EthSpec>(
                         .or(post_gas_limit)
                         .or(post_std_keystores)
                         .or(post_std_remotekeys)
+                        .or(post_graffiti)
                         .recover(warp_utils::reject::handle_rejection),
                 ))
                 .or(warp::patch()
@@ -1199,6 +1287,7 @@ pub fn serve<T: 'static + SlotClock + Clone, E: EthSpec>(
                         .or(delete_gas_limit)
                         .or(delete_std_keystores)
                         .or(delete_std_remotekeys)
+                        .or(delete_graffiti)
                         .recover(warp_utils::reject::handle_rejection),
                 )),
         )
diff --git a/validator_client/src/http_api/tests.rs b/validator_client/src/http_api/tests.rs
index 5f59e35c7..7de3cea21 100644
--- a/validator_client/src/http_api/tests.rs
+++ b/validator_client/src/http_api/tests.rs
@@ -640,6 +640,49 @@ impl ApiTester {
 
         self
     }
+
+    pub async fn test_set_graffiti(self, index: usize, graffiti: &str) -> Self {
+        let validator = &self.client.get_lighthouse_validators().await.unwrap().data[index];
+        let graffiti_str = GraffitiString::from_str(graffiti).unwrap();
+        let resp = self
+            .client
+            .set_graffiti(&validator.voting_pubkey, graffiti_str)
+            .await;
+
+        assert!(resp.is_ok());
+
+        self
+    }
+
+    pub async fn test_delete_graffiti(self, index: usize) -> Self {
+        let validator = &self.client.get_lighthouse_validators().await.unwrap().data[index];
+        let resp = self.client.get_graffiti(&validator.voting_pubkey).await;
+
+        assert!(resp.is_ok());
+        let old_graffiti = resp.unwrap().graffiti;
+
+        let resp = self.client.delete_graffiti(&validator.voting_pubkey).await;
+
+        assert!(resp.is_ok());
+
+        let resp = self.client.get_graffiti(&validator.voting_pubkey).await;
+
+        assert!(resp.is_ok());
+        assert_ne!(old_graffiti, resp.unwrap().graffiti);
+
+        self
+    }
+
+    pub async fn test_get_graffiti(self, index: usize, expected_graffiti: &str) -> Self {
+        let validator = &self.client.get_lighthouse_validators().await.unwrap().data[index];
+        let expected_graffiti_str = GraffitiString::from_str(expected_graffiti).unwrap();
+        let resp = self.client.get_graffiti(&validator.voting_pubkey).await;
+
+        assert!(resp.is_ok());
+        assert_eq!(&resp.unwrap().graffiti, &expected_graffiti_str.into());
+
+        self
+    }
 }
 
 struct HdValidatorScenario {
@@ -771,6 +814,20 @@ async fn routes_with_invalid_auth() {
                 })
                 .await
         })
+        .await
+        .test_with_invalid_auth(|client| async move {
+            client.delete_graffiti(&PublicKeyBytes::empty()).await
+        })
+        .await
+        .test_with_invalid_auth(|client| async move {
+            client.get_graffiti(&PublicKeyBytes::empty()).await
+        })
+        .await
+        .test_with_invalid_auth(|client| async move {
+            client
+                .set_graffiti(&PublicKeyBytes::empty(), GraffitiString::default())
+                .await
+        })
         .await;
 }
 
@@ -954,6 +1011,31 @@ async fn validator_graffiti() {
         .await;
 }
 
+#[tokio::test]
+async fn validator_graffiti_api() {
+    ApiTester::new()
+        .await
+        .create_hd_validators(HdValidatorScenario {
+            count: 2,
+            specify_mnemonic: false,
+            key_derivation_path_offset: 0,
+            disabled: vec![],
+        })
+        .await
+        .assert_enabled_validators_count(2)
+        .assert_validators_count(2)
+        .set_graffiti(0, "Mr F was here")
+        .await
+        .test_get_graffiti(0, "Mr F was here")
+        .await
+        .test_set_graffiti(0, "Uncle Bill was here")
+        .await
+        .test_get_graffiti(0, "Uncle Bill was here")
+        .await
+        .test_delete_graffiti(0)
+        .await;
+}
+
 #[tokio::test]
 async fn keystore_validator_creation() {
     ApiTester::new()
diff --git a/validator_client/src/initialized_validators.rs b/validator_client/src/initialized_validators.rs
index f15ea27c9..b65dad4c4 100644
--- a/validator_client/src/initialized_validators.rs
+++ b/validator_client/src/initialized_validators.rs
@@ -716,6 +716,74 @@ impl InitializedValidators {
         self.validators.get(public_key).and_then(|v| v.graffiti)
     }
 
+    /// Sets the `InitializedValidator` and `ValidatorDefinition` `graffiti` values.
+    ///
+    /// ## Notes
+    ///
+    /// Setting a validator `graffiti` will cause `self.definitions` to be updated and saved to
+    /// disk.
+    ///
+    /// Saves the `ValidatorDefinitions` to file, even if no definitions were changed.
+    pub fn set_graffiti(
+        &mut self,
+        voting_public_key: &PublicKey,
+        graffiti: GraffitiString,
+    ) -> Result<(), Error> {
+        if let Some(def) = self
+            .definitions
+            .as_mut_slice()
+            .iter_mut()
+            .find(|def| def.voting_public_key == *voting_public_key)
+        {
+            def.graffiti = Some(graffiti.clone());
+        }
+
+        if let Some(val) = self
+            .validators
+            .get_mut(&PublicKeyBytes::from(voting_public_key))
+        {
+            val.graffiti = Some(graffiti.into());
+        }
+
+        self.definitions
+            .save(&self.validators_dir)
+            .map_err(Error::UnableToSaveDefinitions)?;
+        Ok(())
+    }
+
+    /// Removes the `InitializedValidator` and `ValidatorDefinition` `graffiti` values.
+    ///
+    /// ## Notes
+    ///
+    /// Removing a validator `graffiti` will cause `self.definitions` to be updated and saved to
+    /// disk. The graffiti for the validator will then fall back to the process level default if
+    /// it is set.
+    ///
+    /// Saves the `ValidatorDefinitions` to file, even if no definitions were changed.
+    pub fn delete_graffiti(&mut self, voting_public_key: &PublicKey) -> Result<(), Error> {
+        if let Some(def) = self
+            .definitions
+            .as_mut_slice()
+            .iter_mut()
+            .find(|def| def.voting_public_key == *voting_public_key)
+        {
+            def.graffiti = None;
+        }
+
+        if let Some(val) = self
+            .validators
+            .get_mut(&PublicKeyBytes::from(voting_public_key))
+        {
+            val.graffiti = None;
+        }
+
+        self.definitions
+            .save(&self.validators_dir)
+            .map_err(Error::UnableToSaveDefinitions)?;
+
+        Ok(())
+    }
+
     /// Returns a `HashMap` of `public_key` -> `graffiti` for all initialized validators.
     pub fn get_all_validators_graffiti(&self) -> HashMap<&PublicKeyBytes, Option<Graffiti>> {
         let mut result = HashMap::new();