diff --git a/.gitignore b/.gitignore
index ae9f83c46..2c656632a 100644
--- a/.gitignore
+++ b/.gitignore
@@ -12,3 +12,6 @@ genesis.ssz
 
 # IntelliJ
 /*.iml
+
+# VSCode
+/.vscode
\ No newline at end of file
diff --git a/beacon_node/beacon_chain/src/beacon_chain.rs b/beacon_node/beacon_chain/src/beacon_chain.rs
index 221d380a8..741d9a95b 100644
--- a/beacon_node/beacon_chain/src/beacon_chain.rs
+++ b/beacon_node/beacon_chain/src/beacon_chain.rs
@@ -611,10 +611,10 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
                 start_slot,
                 end_slot,
                 || {
-                    (
+                    Ok((
                         head.beacon_state.clone_with_only_committee_caches(),
                         head.beacon_block_root,
-                    )
+                    ))
                 },
                 &self.spec,
             )?;
@@ -708,10 +708,10 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
                 start_slot,
                 end_slot,
                 || {
-                    (
+                    Ok((
                         head.beacon_state.clone_with_only_committee_caches(),
                         head.beacon_state_root(),
-                    )
+                    ))
                 },
                 &self.spec,
             )?;
@@ -2878,7 +2878,7 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
         // is so we don't have to think about lock ordering with respect to the fork choice lock.
         // There are a bunch of places where we lock both fork choice and the pubkey cache and it
         // would be difficult to check that they all lock fork choice first.
-        let mut kv_store_ops = self
+        let mut ops = self
             .validator_pubkey_cache
             .try_write_for(VALIDATOR_PUBKEY_CACHE_LOCK_TIMEOUT)
             .ok_or(Error::ValidatorPubkeyCacheLockTimeout)?
@@ -2981,9 +2981,14 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
         // ---------------------------- BLOCK PROBABLY ATTESTABLE ----------------------------------
         // Most blocks are now capable of being attested to thanks to the `early_attester_cache`
         // cache above. Resume non-essential processing.
+        //
+        // It is important NOT to return errors here before the database commit, because the block
+        // has already been added to fork choice and the database would be left in an inconsistent
+        // state if we returned early without committing. In other words, an error here would
+        // corrupt the node's database permanently.
         // -----------------------------------------------------------------------------------------
 
-        self.import_block_update_shuffling_cache(block_root, &mut state)?;
+        self.import_block_update_shuffling_cache(block_root, &mut state);
         self.import_block_observe_attestations(
             block,
             &state,
@@ -3008,25 +3013,39 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
         // See https://github.com/sigp/lighthouse/issues/2028
         let (signed_block, blobs) = signed_block.deconstruct();
         let block = signed_block.message();
-        let mut ops: Vec<_> = confirmed_state_roots
-            .into_iter()
-            .map(StoreOp::DeleteStateTemporaryFlag)
-            .collect();
+        ops.extend(
+            confirmed_state_roots
+                .into_iter()
+                .map(StoreOp::DeleteStateTemporaryFlag),
+        );
         ops.push(StoreOp::PutBlock(block_root, signed_block.clone()));
         ops.push(StoreOp::PutState(block.state_root(), &state));
 
-        if let Some(blobs) = blobs {
-            if blobs.blobs.len() > 0 {
-                //FIXME(sean) using this for debugging for now
-                info!(self.log, "Writing blobs to store"; "block_root" => ?block_root);
-                ops.push(StoreOp::PutBlobs(block_root, blobs));
+        // Only consider blobs if the eip4844 fork is enabled.
+        if let Some(data_availability_boundary) = self.data_availability_boundary() {
+            let block_epoch = block.slot().epoch(T::EthSpec::slots_per_epoch());
+            let margin_epochs = self.store.get_config().blob_prune_margin_epochs;
+            let import_boundary = data_availability_boundary - margin_epochs;
+
+            // Only store blobs at the data availability boundary, minus any configured epochs
+            // margin, or younger (of higher epoch number).
+            if block_epoch >= import_boundary {
+                if let Some(blobs) = blobs {
+                    if blobs.blobs.len() > 0 {
+                        //FIXME(sean) using this for debugging for now
+                        info!(
+                            self.log, "Writing blobs to store";
+                            "block_root" => ?block_root
+                        );
+                        ops.push(StoreOp::PutBlobs(block_root, blobs));
+                    }
+                }
             }
-        };
+        }
+
         let txn_lock = self.store.hot_db.begin_rw_transaction();
 
-        kv_store_ops.extend(self.store.convert_to_kv_batch(ops)?);
-
-        if let Err(e) = self.store.hot_db.do_atomically(kv_store_ops) {
+        if let Err(e) = self.store.do_atomically(ops) {
             error!(
                 self.log,
                 "Database write failed!";
@@ -3455,13 +3474,27 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
         }
     }
 
+    // For the current and next epoch of this state, ensure we have the shuffling from this
+    // block in our cache.
     fn import_block_update_shuffling_cache(
         &self,
         block_root: Hash256,
         state: &mut BeaconState<T::EthSpec>,
+    ) {
+        if let Err(e) = self.import_block_update_shuffling_cache_fallible(block_root, state) {
+            warn!(
+                self.log,
+                "Failed to prime shuffling cache";
+                "error" => ?e
+            );
+        }
+    }
+
+    fn import_block_update_shuffling_cache_fallible(
+        &self,
+        block_root: Hash256,
+        state: &mut BeaconState<T::EthSpec>,
     ) -> Result<(), BlockError<T::EthSpec>> {
-        // For the current and next epoch of this state, ensure we have the shuffling from this
-        // block in our cache.
         for relative_epoch in [RelativeEpoch::Current, RelativeEpoch::Next] {
             let shuffling_id = AttestationShufflingId::new(block_root, state, relative_epoch)?;
 
diff --git a/beacon_node/beacon_chain/src/builder.rs b/beacon_node/beacon_chain/src/builder.rs
index 164ed8a93..0fd016e0b 100644
--- a/beacon_node/beacon_chain/src/builder.rs
+++ b/beacon_node/beacon_chain/src/builder.rs
@@ -914,6 +914,11 @@ where
             );
         }
 
+        // Prune blobs sidecars older than the blob data availability boundary in the background.
+        beacon_chain
+            .store_migrator
+            .process_prune_blobs(beacon_chain.data_availability_boundary());
+
         Ok(beacon_chain)
     }
 }
diff --git a/beacon_node/beacon_chain/src/canonical_head.rs b/beacon_node/beacon_chain/src/canonical_head.rs
index 19eddf602..0d14e3819 100644
--- a/beacon_node/beacon_chain/src/canonical_head.rs
+++ b/beacon_node/beacon_chain/src/canonical_head.rs
@@ -751,6 +751,10 @@ impl<T: BeaconChainTypes> BeaconChain<T> {
         // Drop the old cache head nice and early to try and free the memory as soon as possible.
         drop(old_cached_head);
 
+        // Prune blobs in the background.
+        self.store_migrator
+            .process_prune_blobs(self.data_availability_boundary());
+
         // If the finalized checkpoint changed, perform some updates.
         //
         // The `after_finalization` function will take a write-lock on `fork_choice`, therefore it
diff --git a/beacon_node/beacon_chain/src/migrate.rs b/beacon_node/beacon_chain/src/migrate.rs
index 66f082742..0690d0767 100644
--- a/beacon_node/beacon_chain/src/migrate.rs
+++ b/beacon_node/beacon_chain/src/migrate.rs
@@ -86,6 +86,7 @@ pub enum PruningError {
 pub enum Notification {
     Finalization(FinalizationNotification),
     Reconstruction,
+    PruneBlobs(Option<Epoch>),
 }
 
 pub struct FinalizationNotification {
@@ -152,6 +153,14 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> BackgroundMigrator<E, Ho
         }
     }
 
+    pub fn process_prune_blobs(&self, data_availability_boundary: Option<Epoch>) {
+        if let Some(Notification::PruneBlobs(data_availability_boundary)) =
+            self.send_background_notification(Notification::PruneBlobs(data_availability_boundary))
+        {
+            Self::run_prune_blobs(self.db.clone(), data_availability_boundary, &self.log);
+        }
+    }
+
     pub fn run_reconstruction(db: Arc<HotColdDB<E, Hot, Cold>>, log: &Logger) {
         if let Err(e) = db.reconstruct_historic_states() {
             error!(
@@ -162,6 +171,20 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> BackgroundMigrator<E, Ho
         }
     }
 
+    pub fn run_prune_blobs(
+        db: Arc<HotColdDB<E, Hot, Cold>>,
+        data_availability_boundary: Option<Epoch>,
+        log: &Logger,
+    ) {
+        if let Err(e) = db.try_prune_blobs(false, data_availability_boundary) {
+            error!(
+                log,
+                "Blobs pruning failed";
+                "error" => ?e,
+            );
+        }
+    }
+
     /// If configured to run in the background, send `notif` to the background thread.
     ///
     /// Return `None` if the message was sent to the background thread, `Some(notif)` otherwise.
@@ -320,11 +343,21 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> BackgroundMigrator<E, Ho
                                     best
                                 }
                             }
+                            (Notification::Finalization(_), Notification::PruneBlobs(_)) => best,
+                            (Notification::PruneBlobs(_), Notification::Finalization(_)) => other,
+                            (Notification::PruneBlobs(dab1), Notification::PruneBlobs(dab2)) => {
+                                if dab2 > dab1 {
+                                    other
+                                } else {
+                                    best
+                                }
+                            }
                         });
 
                 match notif {
                     Notification::Reconstruction => Self::run_reconstruction(db.clone(), &log),
                     Notification::Finalization(fin) => Self::run_migration(db.clone(), fin, &log),
+                    Notification::PruneBlobs(dab) => Self::run_prune_blobs(db.clone(), dab, &log),
                 }
             }
         });
@@ -569,10 +602,18 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> BackgroundMigrator<E, Ho
             .into_iter()
             .map(Into::into)
             .flat_map(|block_root: Hash256| {
-                [
+                let mut store_ops = vec![
                     StoreOp::DeleteBlock(block_root),
                     StoreOp::DeleteExecutionPayload(block_root),
-                ]
+                ];
+                if let Ok(true) = store.blobs_sidecar_exists(&block_root) {
+                    // Keep track of non-empty orphaned blobs sidecars.
+                    store_ops.extend([
+                        StoreOp::DeleteBlobs(block_root),
+                        StoreOp::PutOrphanedBlobsKey(block_root),
+                    ]);
+                }
+                store_ops
             })
             .chain(
                 abandoned_states
diff --git a/beacon_node/beacon_chain/src/validator_pubkey_cache.rs b/beacon_node/beacon_chain/src/validator_pubkey_cache.rs
index 26aea2d27..79910df29 100644
--- a/beacon_node/beacon_chain/src/validator_pubkey_cache.rs
+++ b/beacon_node/beacon_chain/src/validator_pubkey_cache.rs
@@ -4,7 +4,7 @@ use ssz::{Decode, Encode};
 use std::collections::HashMap;
 use std::convert::TryInto;
 use std::marker::PhantomData;
-use store::{DBColumn, Error as StoreError, KeyValueStore, KeyValueStoreOp, StoreItem};
+use store::{DBColumn, Error as StoreError, StoreItem, StoreOp};
 use types::{BeaconState, Hash256, PublicKey, PublicKeyBytes};
 
 /// Provides a mapping of `validator_index -> validator_publickey`.
@@ -38,7 +38,7 @@ impl<T: BeaconChainTypes> ValidatorPubkeyCache<T> {
         };
 
         let store_ops = cache.import_new_pubkeys(state)?;
-        store.hot_db.do_atomically(store_ops)?;
+        store.do_atomically(store_ops)?;
 
         Ok(cache)
     }
@@ -79,7 +79,7 @@ impl<T: BeaconChainTypes> ValidatorPubkeyCache<T> {
     pub fn import_new_pubkeys(
         &mut self,
         state: &BeaconState<T::EthSpec>,
-    ) -> Result<Vec<KeyValueStoreOp>, BeaconChainError> {
+    ) -> Result<Vec<StoreOp<'static, T::EthSpec>>, BeaconChainError> {
         if state.validators().len() > self.pubkeys.len() {
             self.import(
                 state.validators()[self.pubkeys.len()..]
@@ -92,7 +92,10 @@ impl<T: BeaconChainTypes> ValidatorPubkeyCache<T> {
     }
 
     /// Adds zero or more validators to `self`.
-    fn import<I>(&mut self, validator_keys: I) -> Result<Vec<KeyValueStoreOp>, BeaconChainError>
+    fn import<I>(
+        &mut self,
+        validator_keys: I,
+    ) -> Result<Vec<StoreOp<'static, T::EthSpec>>, BeaconChainError>
     where
         I: Iterator<Item = PublicKeyBytes> + ExactSizeIterator,
     {
@@ -112,7 +115,9 @@ impl<T: BeaconChainTypes> ValidatorPubkeyCache<T> {
             // It will be committed atomically when the block that introduced it is written to disk.
             // Notably it is NOT written while the write lock on the cache is held.
             // See: https://github.com/sigp/lighthouse/issues/2327
-            store_ops.push(DatabasePubkey(pubkey).as_kv_store_op(DatabasePubkey::key_for_index(i)));
+            store_ops.push(StoreOp::KeyValueOp(
+                DatabasePubkey(pubkey).as_kv_store_op(DatabasePubkey::key_for_index(i)),
+            ));
 
             self.pubkeys.push(
                 (&pubkey)
@@ -294,7 +299,7 @@ mod test {
         let ops = cache
             .import_new_pubkeys(&state)
             .expect("should import pubkeys");
-        store.hot_db.do_atomically(ops).unwrap();
+        store.do_atomically(ops).unwrap();
         check_cache_get(&cache, &keypairs[..]);
         drop(cache);
 
diff --git a/beacon_node/network/src/beacon_processor/worker/rpc_methods.rs b/beacon_node/network/src/beacon_processor/worker/rpc_methods.rs
index 0bd4eebcc..01b7cb43b 100644
--- a/beacon_node/network/src/beacon_processor/worker/rpc_methods.rs
+++ b/beacon_node/network/src/beacon_processor/worker/rpc_methods.rs
@@ -688,12 +688,10 @@ impl<T: BeaconChainTypes> Worker<T> {
         let serve_blobs_from_slot = if start_epoch < data_availability_boundary {
             // Attempt to serve from the earliest block in our database, falling back to the data
             // availability boundary
-            let oldest_blob_slot = self
-                .chain
-                .store
-                .get_blob_info()
-                .map(|blob_info| blob_info.oldest_blob_slot)
-                .unwrap_or(data_availability_boundary.start_slot(T::EthSpec::slots_per_epoch()));
+            let oldest_blob_slot =
+                self.chain.store.get_blob_info().oldest_blob_slot.unwrap_or(
+                    data_availability_boundary.start_slot(T::EthSpec::slots_per_epoch()),
+                );
 
             debug!(
                 self.log,
diff --git a/beacon_node/src/cli.rs b/beacon_node/src/cli.rs
index c5aef78aa..e711dfca9 100644
--- a/beacon_node/src/cli.rs
+++ b/beacon_node/src/cli.rs
@@ -551,6 +551,31 @@ pub fn cli_app<'a, 'b>() -> App<'a, 'b> {
                 .takes_value(true)
                 .default_value("true")
         )
+        .arg(
+            Arg::with_name("prune-blobs")
+                .long("prune-blobs")
+                .help("Prune blobs from Lighthouse's database when they are older than the data \
+                       data availability boundary relative to the current epoch.")
+                .takes_value(true)
+                .default_value("true")
+        )
+        .arg(
+            Arg::with_name("epochs-per-blob-prune")
+                .long("epochs-per-blob-prune")
+                .help("The epoch interval with which to prune blobs from Lighthouse's \
+                       database when they are older than the data availability boundary \
+                       relative to the current epoch.")
+                .takes_value(true)
+                .default_value("1")
+        )
+        .arg(
+            Arg::with_name("blob-prune-margin-epochs")
+                .long("blob-prune-margin-epochs")
+                .help("The margin for blob pruning in epochs. The oldest blobs are pruned \
+                       up until data_availability_boundary - blob_prune_margin_epochs.")
+                .takes_value(true)
+                .default_value("0")
+        )
 
         /*
          * Misc.
diff --git a/beacon_node/src/config.rs b/beacon_node/src/config.rs
index 1ce0f5f77..7ced91274 100644
--- a/beacon_node/src/config.rs
+++ b/beacon_node/src/config.rs
@@ -411,6 +411,22 @@ pub fn get_config<E: EthSpec>(
         client_config.store.prune_payloads = prune_payloads;
     }
 
+    if let Some(prune_blobs) = clap_utils::parse_optional(cli_args, "prune-blobs")? {
+        client_config.store.prune_blobs = prune_blobs;
+    }
+
+    if let Some(epochs_per_blob_prune) =
+        clap_utils::parse_optional(cli_args, "epochs-per-blob-prune")?
+    {
+        client_config.store.epochs_per_blob_prune = epochs_per_blob_prune;
+    }
+
+    if let Some(blob_prune_margin_epochs) =
+        clap_utils::parse_optional(cli_args, "blob-prune-margin-epochs")?
+    {
+        client_config.store.blob_prune_margin_epochs = blob_prune_margin_epochs;
+    }
+
     /*
      * Zero-ports
      *
diff --git a/beacon_node/store/src/config.rs b/beacon_node/store/src/config.rs
index 53d99f75e..ec5ee382b 100644
--- a/beacon_node/store/src/config.rs
+++ b/beacon_node/store/src/config.rs
@@ -8,6 +8,8 @@ pub const PREV_DEFAULT_SLOTS_PER_RESTORE_POINT: u64 = 2048;
 pub const DEFAULT_SLOTS_PER_RESTORE_POINT: u64 = 8192;
 pub const DEFAULT_BLOCK_CACHE_SIZE: usize = 5;
 pub const DEFAULT_BLOB_CACHE_SIZE: usize = 5;
+pub const DEFAULT_EPOCHS_PER_BLOB_PRUNE: u64 = 1;
+pub const DEFAULT_BLOB_PUNE_MARGIN_EPOCHS: u64 = 0;
 
 /// Database configuration parameters.
 #[derive(Debug, Clone, PartialEq, Eq, Serialize, Deserialize)]
@@ -26,6 +28,13 @@ pub struct StoreConfig {
     pub compact_on_prune: bool,
     /// Whether to prune payloads on initialization and finalization.
     pub prune_payloads: bool,
+    /// Whether to prune blobs older than the blob data availability boundary.
+    pub prune_blobs: bool,
+    /// Frequency of blob pruning in epochs. Default: 1 (every epoch).
+    pub epochs_per_blob_prune: u64,
+    /// The margin for blob pruning in epochs. The oldest blobs are pruned up until
+    /// data_availability_boundary - blob_prune_margin_epochs. Default: 0.
+    pub blob_prune_margin_epochs: u64,
 }
 
 /// Variant of `StoreConfig` that gets written to disk. Contains immutable configuration params.
@@ -50,6 +59,9 @@ impl Default for StoreConfig {
             compact_on_init: false,
             compact_on_prune: true,
             prune_payloads: true,
+            prune_blobs: true,
+            epochs_per_blob_prune: DEFAULT_EPOCHS_PER_BLOB_PRUNE,
+            blob_prune_margin_epochs: DEFAULT_BLOB_PUNE_MARGIN_EPOCHS,
         }
     }
 }
diff --git a/beacon_node/store/src/errors.rs b/beacon_node/store/src/errors.rs
index 8a0b44197..ac50cc6aa 100644
--- a/beacon_node/store/src/errors.rs
+++ b/beacon_node/store/src/errors.rs
@@ -19,6 +19,8 @@ pub enum Error {
     },
     RlpError(String),
     BlockNotFound(Hash256),
+    /// The blobs sidecar mapping to this block root is older than the data availability boundary.
+    BlobsTooOld(Hash256, Slot),
     NoContinuationData,
     SplitPointModified(Slot, Slot),
     ConfigError(StoreConfigError),
diff --git a/beacon_node/store/src/forwards_iter.rs b/beacon_node/store/src/forwards_iter.rs
index 353be6bf0..a78b2b469 100644
--- a/beacon_node/store/src/forwards_iter.rs
+++ b/beacon_node/store/src/forwards_iter.rs
@@ -150,7 +150,7 @@ impl<'a, E: EthSpec, F: Root<E>, Hot: ItemStore<E>, Cold: ItemStore<E>>
         store: &'a HotColdDB<E, Hot, Cold>,
         start_slot: Slot,
         end_slot: Option<Slot>,
-        get_state: impl FnOnce() -> (BeaconState<E>, Hash256),
+        get_state: impl FnOnce() -> Result<(BeaconState<E>, Hash256)>,
         spec: &ChainSpec,
     ) -> Result<Self> {
         use HybridForwardsIterator::*;
@@ -172,7 +172,7 @@ impl<'a, E: EthSpec, F: Root<E>, Hot: ItemStore<E>, Cold: ItemStore<E>>
                 if end_slot.map_or(false, |end_slot| end_slot < latest_restore_point_slot) {
                     None
                 } else {
-                    Some(Box::new(get_state()))
+                    Some(Box::new(get_state()?))
                 };
             PreFinalization {
                 iter,
@@ -180,7 +180,7 @@ impl<'a, E: EthSpec, F: Root<E>, Hot: ItemStore<E>, Cold: ItemStore<E>>
             }
         } else {
             PostFinalizationLazy {
-                continuation_data: Some(Box::new(get_state())),
+                continuation_data: Some(Box::new(get_state()?)),
                 store,
                 start_slot,
             }
diff --git a/beacon_node/store/src/hot_cold_store.rs b/beacon_node/store/src/hot_cold_store.rs
index 82a65883a..99b516ee9 100644
--- a/beacon_node/store/src/hot_cold_store.rs
+++ b/beacon_node/store/src/hot_cold_store.rs
@@ -38,6 +38,7 @@ use std::marker::PhantomData;
 use std::path::Path;
 use std::sync::Arc;
 use std::time::Duration;
+use types::consts::eip4844::MIN_EPOCHS_FOR_BLOBS_SIDECARS_REQUESTS;
 use types::*;
 
 /// On-disk database that stores finalized states efficiently.
@@ -54,7 +55,7 @@ pub struct HotColdDB<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> {
     /// The starting slots for the range of blocks & states stored in the database.
     anchor_info: RwLock<Option<AnchorInfo>>,
     /// The starting slots for the range of blobs stored in the database.
-    blob_info: RwLock<Option<BlobInfo>>,
+    blob_info: RwLock<BlobInfo>,
     pub(crate) config: StoreConfig,
     /// Cold database containing compact historical data.
     pub cold_db: Cold,
@@ -108,6 +109,7 @@ pub enum HotColdDBError {
         slots_per_historical_root: u64,
         slots_per_epoch: u64,
     },
+    ZeroEpochsPerBlobPrune,
     RestorePointBlockHashError(BeaconStateError),
     IterationError {
         unexpected_key: BytesKey,
@@ -125,12 +127,12 @@ impl<E: EthSpec> HotColdDB<E, MemoryStore<E>, MemoryStore<E>> {
         spec: ChainSpec,
         log: Logger,
     ) -> Result<HotColdDB<E, MemoryStore<E>, MemoryStore<E>>, Error> {
-        Self::verify_slots_per_restore_point(config.slots_per_restore_point)?;
+        Self::verify_config(&config)?;
 
         let db = HotColdDB {
             split: RwLock::new(Split::default()),
             anchor_info: RwLock::new(None),
-            blob_info: RwLock::new(None),
+            blob_info: RwLock::new(BlobInfo::default()),
             cold_db: MemoryStore::open(),
             hot_db: MemoryStore::open(),
             block_cache: Mutex::new(LruCache::new(config.block_cache_size)),
@@ -165,7 +167,7 @@ impl<E: EthSpec> HotColdDB<E, LevelDB<E>, LevelDB<E>> {
         let mut db = HotColdDB {
             split: RwLock::new(Split::default()),
             anchor_info: RwLock::new(None),
-            blob_info: RwLock::new(None),
+            blob_info: RwLock::new(BlobInfo::default()),
             cold_db: LevelDB::open(cold_path)?,
             hot_db: LevelDB::open(hot_path)?,
             block_cache: Mutex::new(LruCache::new(config.block_cache_size)),
@@ -226,6 +228,17 @@ impl<E: EthSpec> HotColdDB<E, LevelDB<E>, LevelDB<E>> {
             db.store_schema_version(CURRENT_SCHEMA_VERSION)?;
         }
 
+        if let Some(blob_info) = db.load_blob_info()? {
+            let oldest_blob_slot = blob_info.oldest_blob_slot;
+            *db.blob_info.write() = blob_info;
+
+            info!(
+                db.log,
+                "Blob info loaded from disk";
+                "oldest_blob_slot" => ?oldest_blob_slot,
+            );
+        }
+
         // Ensure that any on-disk config is compatible with the supplied config.
         if let Some(disk_config) = db.load_config()? {
             db.config.check_compatibility(&disk_config)?;
@@ -477,6 +490,12 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
             .map(|payload| payload.is_some())
     }
 
+    /// Check if the blobs sidecar for a block exists on disk.
+    pub fn blobs_sidecar_exists(&self, block_root: &Hash256) -> Result<bool, Error> {
+        self.get_item::<BlobsSidecar<E>>(block_root)
+            .map(|blobs| blobs.is_some())
+    }
+
     /// Determine whether a block exists in the database.
     pub fn block_exists(&self, block_root: &Hash256) -> Result<bool, Error> {
         self.hot_db
@@ -646,7 +665,7 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
             self,
             start_slot,
             None,
-            || (end_state, end_block_root),
+            || Ok((end_state, end_block_root)),
             spec,
         )
     }
@@ -655,7 +674,7 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
         &self,
         start_slot: Slot,
         end_slot: Slot,
-        get_state: impl FnOnce() -> (BeaconState<E>, Hash256),
+        get_state: impl FnOnce() -> Result<(BeaconState<E>, Hash256), Error>,
         spec: &ChainSpec,
     ) -> Result<HybridForwardsBlockRootsIterator<E, Hot, Cold>, Error> {
         HybridForwardsBlockRootsIterator::new(self, start_slot, Some(end_slot), get_state, spec)
@@ -672,7 +691,7 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
             self,
             start_slot,
             None,
-            || (end_state, end_state_root),
+            || Ok((end_state, end_state_root)),
             spec,
         )
     }
@@ -681,7 +700,7 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
         &self,
         start_slot: Slot,
         end_slot: Slot,
-        get_state: impl FnOnce() -> (BeaconState<E>, Hash256),
+        get_state: impl FnOnce() -> Result<(BeaconState<E>, Hash256), Error>,
         spec: &ChainSpec,
     ) -> Result<HybridForwardsStateRootsIterator<E, Hot, Cold>, Error> {
         HybridForwardsStateRootsIterator::new(self, start_slot, Some(end_slot), get_state, spec)
@@ -777,6 +796,11 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
                     key_value_batch.push(KeyValueStoreOp::DeleteKey(key));
                 }
 
+                StoreOp::DeleteBlobs(block_root) => {
+                    let key = get_key_for_col(DBColumn::BeaconBlob.into(), block_root.as_bytes());
+                    key_value_batch.push(KeyValueStoreOp::DeleteKey(key));
+                }
+
                 StoreOp::DeleteState(state_root, slot) => {
                     let state_summary_key =
                         get_key_for_col(DBColumn::BeaconStateSummary.into(), state_root.as_bytes());
@@ -793,6 +817,16 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
                     let key = get_key_for_col(DBColumn::ExecPayload.into(), block_root.as_bytes());
                     key_value_batch.push(KeyValueStoreOp::DeleteKey(key));
                 }
+
+                StoreOp::PutOrphanedBlobsKey(block_root) => {
+                    let db_key =
+                        get_key_for_col(DBColumn::BeaconBlobOrphan.into(), block_root.as_bytes());
+                    key_value_batch.push(KeyValueStoreOp::PutKeyValue(db_key, [].into()));
+                }
+
+                StoreOp::KeyValueOp(kv_op) => {
+                    key_value_batch.push(kv_op);
+                }
             }
         }
         Ok(key_value_batch)
@@ -826,15 +860,24 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
                     guard.pop(block_root);
                 }
 
+                StoreOp::DeleteBlobs(block_root) => {
+                    guard_blob.pop(block_root);
+                }
+
                 StoreOp::DeleteState(_, _) => (),
 
                 StoreOp::DeleteExecutionPayload(_) => (),
+
+                StoreOp::PutOrphanedBlobsKey(_) => (),
+
+                StoreOp::KeyValueOp(_) => (),
             }
         }
 
         self.hot_db
             .do_atomically(self.convert_to_kv_batch(batch)?)?;
         drop(guard);
+        drop(guard_blob);
 
         Ok(())
     }
@@ -1046,7 +1089,7 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
         let state_root_iter = self.forwards_state_roots_iterator_until(
             low_restore_point.slot(),
             slot,
-            || (high_restore_point, Hash256::zero()),
+            || Ok((high_restore_point, Hash256::zero())),
             &self.spec,
         )?;
 
@@ -1311,7 +1354,7 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
     /// Get a clone of the store's blob info.
     ///
     /// To do mutations, use `compare_and_set_blob_info`.
-    pub fn get_blob_info(&self) -> Option<BlobInfo> {
+    pub fn get_blob_info(&self) -> BlobInfo {
         self.blob_info.read_recursive().clone()
     }
 
@@ -1322,10 +1365,10 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
     ///
     /// Return an `BlobInfoConcurrentMutation` error if the `prev_value` provided
     /// is not correct.
-    pub fn compare_and_set_blob_info(
+    fn compare_and_set_blob_info(
         &self,
-        prev_value: Option<BlobInfo>,
-        new_value: Option<BlobInfo>,
+        prev_value: BlobInfo,
+        new_value: BlobInfo,
     ) -> Result<KeyValueStoreOp, Error> {
         let mut blob_info = self.blob_info.write();
         if *blob_info == prev_value {
@@ -1333,15 +1376,15 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
             *blob_info = new_value;
             Ok(kv_op)
         } else {
-            Err(Error::AnchorInfoConcurrentMutation)
+            Err(Error::BlobInfoConcurrentMutation)
         }
     }
 
     /// As for `compare_and_set_blob_info`, but also writes the blob info to disk immediately.
-    pub fn compare_and_set_blob_info_with_write(
+    fn compare_and_set_blob_info_with_write(
         &self,
-        prev_value: Option<BlobInfo>,
-        new_value: Option<BlobInfo>,
+        prev_value: BlobInfo,
+        new_value: BlobInfo,
     ) -> Result<(), Error> {
         let kv_store_op = self.compare_and_set_blob_info(prev_value, new_value)?;
         self.hot_db.do_atomically(vec![kv_store_op])
@@ -1356,15 +1399,8 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
     ///
     /// The argument is intended to be `self.blob_info`, but is passed manually to avoid issues
     /// with recursive locking.
-    fn store_blob_info_in_batch(&self, blob_info: &Option<BlobInfo>) -> KeyValueStoreOp {
-        if let Some(ref blob_info) = blob_info {
-            blob_info.as_kv_store_op(BLOB_INFO_KEY)
-        } else {
-            KeyValueStoreOp::DeleteKey(get_key_for_col(
-                DBColumn::BeaconMeta.into(),
-                BLOB_INFO_KEY.as_bytes(),
-            ))
-        }
+    fn store_blob_info_in_batch(&self, blob_info: &BlobInfo) -> KeyValueStoreOp {
+        blob_info.as_kv_store_op(BLOB_INFO_KEY)
     }
 
     /// Return the slot-window describing the available historic states.
@@ -1487,6 +1523,12 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
         self.hot_db.get(state_root)
     }
 
+    /// Verify that a parsed config.
+    fn verify_config(config: &StoreConfig) -> Result<(), HotColdDBError> {
+        Self::verify_slots_per_restore_point(config.slots_per_restore_point)?;
+        Self::verify_epochs_per_blob_prune(config.epochs_per_blob_prune)
+    }
+
     /// Check that the restore point frequency is valid.
     ///
     /// Specifically, check that it is:
@@ -1517,6 +1559,16 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
         }
     }
 
+    // Check that epochs_per_blob_prune is at least 1 epoch to avoid attempting to prune the same
+    // epochs over and over again.
+    fn verify_epochs_per_blob_prune(epochs_per_blob_prune: u64) -> Result<(), HotColdDBError> {
+        if epochs_per_blob_prune > 0 {
+            Ok(())
+        } else {
+            Err(HotColdDBError::ZeroEpochsPerBlobPrune)
+        }
+    }
+
     /// Run a compaction pass to free up space used by deleted states.
     pub fn compact(&self) -> Result<(), Error> {
         self.hot_db.compact()?;
@@ -1669,6 +1721,166 @@ impl<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>> HotColdDB<E, Hot, Cold>
         );
         Ok(())
     }
+
+    ///  Try to prune blobs, approximating the current epoch from lower epoch numbers end (older
+    /// end) and is useful when the data availability boundary is not at hand.
+    pub fn try_prune_most_blobs(&self, force: bool) -> Result<(), Error> {
+        let eip4844_fork = match self.spec.eip4844_fork_epoch {
+            Some(epoch) => epoch,
+            None => {
+                debug!(self.log, "Eip4844 fork is disabled");
+                return Ok(());
+            }
+        };
+        // At best, current_epoch = split_epoch + 2. However, if finalization doesn't advance, the
+        // `split.slot` is not updated and current_epoch > split_epoch + 2.
+        let min_current_epoch = self.get_split_slot().epoch(E::slots_per_epoch()) + Epoch::new(2);
+        let min_data_availability_boundary = std::cmp::max(
+            eip4844_fork,
+            min_current_epoch.saturating_sub(*MIN_EPOCHS_FOR_BLOBS_SIDECARS_REQUESTS),
+        );
+
+        self.try_prune_blobs(force, Some(min_data_availability_boundary))
+    }
+
+    /// Try to prune blobs older than the data availability boundary.
+    pub fn try_prune_blobs(
+        &self,
+        force: bool,
+        data_availability_boundary: Option<Epoch>,
+    ) -> Result<(), Error> {
+        let (data_availability_boundary, eip4844_fork) =
+            match (data_availability_boundary, self.spec.eip4844_fork_epoch) {
+                (Some(boundary_epoch), Some(fork_epoch)) => (boundary_epoch, fork_epoch),
+                _ => {
+                    debug!(self.log, "Eip4844 fork is disabled");
+                    return Ok(());
+                }
+            };
+
+        let should_prune_blobs = self.get_config().prune_blobs;
+        if !should_prune_blobs && !force {
+            debug!(
+                self.log,
+                "Blob pruning is disabled";
+                "prune_blobs" => should_prune_blobs
+            );
+            return Ok(());
+        }
+
+        let blob_info = self.get_blob_info();
+        let oldest_blob_slot = blob_info
+            .oldest_blob_slot
+            .unwrap_or(eip4844_fork.start_slot(E::slots_per_epoch()));
+
+        // The last entirely pruned epoch, blobs sidecar pruning may have stopped early in the
+        // middle of an epoch otherwise the oldest blob slot is a start slot.
+        let last_pruned_epoch = oldest_blob_slot.epoch(E::slots_per_epoch()) - 1;
+
+        // At most prune blobs up until the data availability boundary epoch, leaving at least
+        // blobs of the data availability boundary epoch and younger.
+        let earliest_prunable_epoch = data_availability_boundary - 1;
+        // Stop pruning before reaching the data availability boundary if a margin is configured.
+        let margin_epochs = self.get_config().blob_prune_margin_epochs;
+        let end_epoch = earliest_prunable_epoch - margin_epochs;
+
+        if !force {
+            if last_pruned_epoch.as_u64() + self.get_config().epochs_per_blob_prune
+                > end_epoch.as_u64()
+            {
+                info!(self.log, "Blobs sidecars are pruned");
+                return Ok(());
+            }
+        }
+
+        // Iterate block roots forwards from the oldest blob slot.
+        debug!(
+            self.log,
+            "Pruning blobs sidecars stored longer than data availability boundary";
+        );
+        // todo(emhane): If we notice degraded I/O for users switching modes (prune_blobs=true to
+        // prune_blobs=false) we could add a warning that only fires on a threshold, e.g. more
+        // than 2x epochs_per_blob_prune epochs without a prune.
+
+        let mut ops = vec![];
+        let mut last_pruned_block_root = None;
+        let end_slot = end_epoch.end_slot(E::slots_per_epoch());
+
+        for res in self.forwards_block_roots_iterator_until(
+            oldest_blob_slot,
+            end_slot,
+            || {
+                // todo(emhane): In the future, if the data availability boundary is more recent
+                // than the split (finalized) epoch, this code will have to change to decide what
+                // to do with pruned blobs in our not-yet-finalized canonical chain and
+                // not-yet-orphaned forks (see DBColumn::BeaconBlobOrphan).
+                //
+                // Related to review and the spec PRs linked in it:
+                // https://github.com/sigp/lighthouse/pull/3852#pullrequestreview-1244785136
+                let split = self.get_split_info();
+
+                let split_state = self.get_state(&split.state_root, Some(split.slot))?.ok_or(
+                    HotColdDBError::MissingSplitState(split.state_root, split.slot),
+                )?;
+                let split_block_root = split_state.get_latest_block_root(split.state_root);
+
+                Ok((split_state, split_block_root))
+            },
+            &self.spec,
+        )? {
+            let (block_root, slot) = match res {
+                Ok(tuple) => tuple,
+                Err(e) => {
+                    warn!(
+                        self.log,
+                        "Stopping blobs sidecar pruning early";
+                        "error" => ?e,
+                    );
+                    break;
+                }
+            };
+
+            if Some(block_root) != last_pruned_block_root
+                && self.blobs_sidecar_exists(&block_root)?
+            {
+                debug!(
+                    self.log,
+                    "Pruning blobs sidecar";
+                    "slot" => slot,
+                    "block_root" => ?block_root,
+                );
+                last_pruned_block_root = Some(block_root);
+                ops.push(StoreOp::DeleteBlobs(block_root));
+            }
+
+            if slot >= end_slot {
+                info!(
+                    self.log,
+                    "Blobs sidecar pruning reached earliest available blobs sidecar";
+                    "slot" => slot
+                );
+                break;
+            }
+        }
+        let blobs_sidecars_pruned = ops.len();
+
+        let update_blob_info = self.compare_and_set_blob_info(
+            blob_info,
+            BlobInfo {
+                oldest_blob_slot: Some(end_slot + 1),
+            },
+        )?;
+        ops.push(StoreOp::KeyValueOp(update_blob_info));
+
+        self.do_atomically(ops)?;
+        info!(
+            self.log,
+            "Blobs sidecar pruning complete";
+            "blobs_sidecars_pruned" => blobs_sidecars_pruned,
+        );
+
+        Ok(())
+    }
 }
 
 /// Advance the split point of the store, moving new finalized states to the freezer.
@@ -1710,6 +1922,7 @@ pub fn migrate_database<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>>(
     // 1. Copy all of the states between the head and the split slot, from the hot DB
     // to the cold DB. Delete the execution payloads of these now-finalized blocks.
     let state_root_iter = RootsIterator::new(&store, frozen_head);
+
     for maybe_tuple in state_root_iter.take_while(|result| match result {
         Ok((_, _, slot)) => {
             slot >= &current_split_slot
@@ -1751,7 +1964,7 @@ pub fn migrate_database<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>>(
     }
 
     // Warning: Critical section.  We have to take care not to put any of the two databases in an
-    //          inconsistent state if the OS process dies at any point during the freezeing
+    //          inconsistent state if the OS process dies at any point during the freezing
     //          procedure.
     //
     // Since it is pretty much impossible to be atomic across more than one database, we trade
@@ -1767,7 +1980,7 @@ pub fn migrate_database<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>>(
         let mut split_guard = store.split.write();
         let latest_split_slot = split_guard.slot;
 
-        // Detect a sitation where the split point is (erroneously) changed from more than one
+        // Detect a situation where the split point is (erroneously) changed from more than one
         // place in code.
         if latest_split_slot != current_split_slot {
             error!(
@@ -1811,7 +2024,7 @@ pub fn migrate_database<E: EthSpec, Hot: ItemStore<E>, Cold: ItemStore<E>>(
 }
 
 /// Struct for storing the split slot and state root in the database.
-#[derive(Debug, Clone, Copy, PartialEq, Default, Encode, Decode, Deserialize, Serialize)]
+#[derive(Debug, Clone, Copy, PartialEq, Eq, Default, Encode, Decode, Deserialize, Serialize)]
 pub struct Split {
     pub(crate) slot: Slot,
     pub(crate) state_root: Hash256,
diff --git a/beacon_node/store/src/impls/execution_payload.rs b/beacon_node/store/src/impls/execution_payload.rs
index ad68d1fba..01a2dba0b 100644
--- a/beacon_node/store/src/impls/execution_payload.rs
+++ b/beacon_node/store/src/impls/execution_payload.rs
@@ -1,7 +1,7 @@
 use crate::{DBColumn, Error, StoreItem};
 use ssz::{Decode, Encode};
 use types::{
-    EthSpec, ExecutionPayload, ExecutionPayloadCapella, ExecutionPayloadEip4844,
+    BlobsSidecar, EthSpec, ExecutionPayload, ExecutionPayloadCapella, ExecutionPayloadEip4844,
     ExecutionPayloadMerge,
 };
 
@@ -25,6 +25,7 @@ macro_rules! impl_store_item {
 impl_store_item!(ExecutionPayloadMerge);
 impl_store_item!(ExecutionPayloadCapella);
 impl_store_item!(ExecutionPayloadEip4844);
+impl_store_item!(BlobsSidecar);
 
 /// This fork-agnostic implementation should be only used for writing.
 ///
diff --git a/beacon_node/store/src/lib.rs b/beacon_node/store/src/lib.rs
index dfdeab941..1d7e92b80 100644
--- a/beacon_node/store/src/lib.rs
+++ b/beacon_node/store/src/lib.rs
@@ -35,6 +35,7 @@ pub use self::hot_cold_store::{HotColdDB, HotStateSummary, Split};
 pub use self::leveldb_store::LevelDB;
 pub use self::memory_store::MemoryStore;
 pub use self::partial_beacon_state::PartialBeaconState;
+pub use crate::metadata::BlobInfo;
 pub use errors::Error;
 pub use impls::beacon_state::StorageContainer as BeaconStateStorageContainer;
 pub use metadata::AnchorInfo;
@@ -157,12 +158,15 @@ pub enum StoreOp<'a, E: EthSpec> {
     PutBlock(Hash256, Arc<SignedBeaconBlock<E>>),
     PutState(Hash256, &'a BeaconState<E>),
     PutBlobs(Hash256, Arc<BlobsSidecar<E>>),
+    PutOrphanedBlobsKey(Hash256),
     PutStateSummary(Hash256, HotStateSummary),
     PutStateTemporaryFlag(Hash256),
     DeleteStateTemporaryFlag(Hash256),
     DeleteBlock(Hash256),
+    DeleteBlobs(Hash256),
     DeleteState(Hash256, Option<Slot>),
     DeleteExecutionPayload(Hash256),
+    KeyValueOp(KeyValueStoreOp),
 }
 
 /// A unique column identifier.
@@ -175,6 +179,9 @@ pub enum DBColumn {
     BeaconBlock,
     #[strum(serialize = "blb")]
     BeaconBlob,
+    /// Block roots of orphaned beacon blobs.
+    #[strum(serialize = "blo")]
+    BeaconBlobOrphan,
     /// For full `BeaconState`s in the hot database (finalized or fork-boundary states).
     #[strum(serialize = "ste")]
     BeaconState,
diff --git a/beacon_node/store/src/metadata.rs b/beacon_node/store/src/metadata.rs
index 15bcaf1bb..b5de0048f 100644
--- a/beacon_node/store/src/metadata.rs
+++ b/beacon_node/store/src/metadata.rs
@@ -120,14 +120,10 @@ impl StoreItem for AnchorInfo {
 }
 
 /// Database parameters relevant to blob sync.
-#[derive(Debug, PartialEq, Eq, Clone, Encode, Decode, Serialize, Deserialize)]
+#[derive(Debug, PartialEq, Eq, Clone, Encode, Decode, Serialize, Deserialize, Default)]
 pub struct BlobInfo {
-    /// The block root of the next blob that needs to be added to fill in the history.
-    pub oldest_blob_parent: Hash256,
-    /// The slot before which blobs are available.
-    pub oldest_blob_slot: Slot,
-    /// The slot from which blobs are available.
-    pub latest_blob_slot: Slot,
+    /// The slot after which blobs are available (>=).
+    pub oldest_blob_slot: Option<Slot>,
 }
 
 impl StoreItem for BlobInfo {
diff --git a/consensus/fork_choice/src/fork_choice.rs b/consensus/fork_choice/src/fork_choice.rs
index f795b0790..f614007ae 100644
--- a/consensus/fork_choice/src/fork_choice.rs
+++ b/consensus/fork_choice/src/fork_choice.rs
@@ -768,7 +768,7 @@ where
             .ok_or_else(|| Error::InvalidBlock(InvalidBlock::UnknownParent(block.parent_root())))?;
 
         // Blocks cannot be in the future. If they are, their consideration must be delayed until
-        // the are in the past.
+        // they are in the past.
         //
         // Note: presently, we do not delay consideration. We just drop the block.
         if block.slot() > current_slot {
diff --git a/consensus/types/src/slot_epoch.rs b/consensus/types/src/slot_epoch.rs
index 2716367c7..06f99b988 100644
--- a/consensus/types/src/slot_epoch.rs
+++ b/consensus/types/src/slot_epoch.rs
@@ -76,8 +76,8 @@ impl Slot {
 }
 
 impl Epoch {
-    pub const fn new(slot: u64) -> Epoch {
-        Epoch(slot)
+    pub const fn new(epoch: u64) -> Epoch {
+        Epoch(epoch)
     }
 
     pub fn max_value() -> Epoch {
diff --git a/database_manager/src/lib.rs b/database_manager/src/lib.rs
index 33accfc05..a33e6c149 100644
--- a/database_manager/src/lib.rs
+++ b/database_manager/src/lib.rs
@@ -65,6 +65,12 @@ pub fn prune_payloads_app<'a, 'b>() -> App<'a, 'b> {
         .about("Prune finalized execution payloads")
 }
 
+pub fn prune_blobs_app<'a, 'b>() -> App<'a, 'b> {
+    App::new("prune_blobs")
+        .setting(clap::AppSettings::ColoredHelp)
+        .about("Prune blobs older than data availability boundary")
+}
+
 pub fn cli_app<'a, 'b>() -> App<'a, 'b> {
     App::new(CMD)
         .visible_aliases(&["db"])
@@ -88,10 +94,21 @@ pub fn cli_app<'a, 'b>() -> App<'a, 'b> {
                 .help("Data directory for the freezer database.")
                 .takes_value(true),
         )
+        .arg(
+            Arg::with_name("blob-prune-margin-epochs")
+                .long("blob-prune-margin-epochs")
+                .help(
+                    "The margin for blob pruning in epochs. The oldest blobs are pruned \
+                       up until data_availability_boundary - blob_prune_margin_epochs.",
+                )
+                .takes_value(true)
+                .default_value("0"),
+        )
         .subcommand(migrate_cli_app())
         .subcommand(version_cli_app())
         .subcommand(inspect_cli_app())
         .subcommand(prune_payloads_app())
+        .subcommand(prune_blobs_app())
 }
 
 fn parse_client_config<E: EthSpec>(
@@ -110,6 +127,12 @@ fn parse_client_config<E: EthSpec>(
     client_config.store.slots_per_restore_point = sprp;
     client_config.store.slots_per_restore_point_set_explicitly = sprp_explicit;
 
+    if let Some(blob_prune_margin_epochs) =
+        clap_utils::parse_optional(cli_args, "blob-prune-margin-epochs")?
+    {
+        client_config.store.blob_prune_margin_epochs = blob_prune_margin_epochs;
+    }
+
     Ok(client_config)
 }
 
@@ -287,6 +310,29 @@ pub fn prune_payloads<E: EthSpec>(
     db.try_prune_execution_payloads(force)
 }
 
+pub fn prune_blobs<E: EthSpec>(
+    client_config: ClientConfig,
+    runtime_context: &RuntimeContext<E>,
+    log: Logger,
+) -> Result<(), Error> {
+    let spec = &runtime_context.eth2_config.spec;
+    let hot_path = client_config.get_db_path();
+    let cold_path = client_config.get_freezer_db_path();
+
+    let db = HotColdDB::<E, LevelDB<E>, LevelDB<E>>::open(
+        &hot_path,
+        &cold_path,
+        |_, _, _| Ok(()),
+        client_config.store,
+        spec.clone(),
+        log,
+    )?;
+
+    // If we're triggering a prune manually then ignore the check on `epochs_per_blob_prune` that
+    // bails out early by passing true to the force parameter.
+    db.try_prune_most_blobs(true)
+}
+
 /// Run the database manager, returning an error string if the operation did not succeed.
 pub fn run<T: EthSpec>(cli_args: &ArgMatches<'_>, env: Environment<T>) -> Result<(), String> {
     let client_config = parse_client_config(cli_args, &env)?;
@@ -304,6 +350,7 @@ pub fn run<T: EthSpec>(cli_args: &ArgMatches<'_>, env: Environment<T>) -> Result
             inspect_db(inspect_config, client_config, &context, log)
         }
         ("prune_payloads", Some(_)) => prune_payloads(client_config, &context, log),
+        ("prune_blobs", Some(_)) => prune_blobs(client_config, &context, log),
         _ => {
             return Err("Unknown subcommand, for help `lighthouse database_manager --help`".into())
         }
diff --git a/lighthouse/tests/beacon_node.rs b/lighthouse/tests/beacon_node.rs
index 7e581ee61..237ca2db5 100644
--- a/lighthouse/tests/beacon_node.rs
+++ b/lighthouse/tests/beacon_node.rs
@@ -1341,6 +1341,45 @@ fn prune_payloads_on_startup_false() {
         .with_config(|config| assert!(!config.store.prune_payloads));
 }
 #[test]
+fn prune_blobs_default() {
+    CommandLineTest::new()
+        .run_with_zero_port()
+        .with_config(|config| assert!(config.store.prune_blobs));
+}
+#[test]
+fn prune_blobs_on_startup_false() {
+    CommandLineTest::new()
+        .flag("prune-blobs", Some("false"))
+        .run_with_zero_port()
+        .with_config(|config| assert!(!config.store.prune_blobs));
+}
+#[test]
+fn epochs_per_blob_prune_default() {
+    CommandLineTest::new()
+        .run_with_zero_port()
+        .with_config(|config| assert!(config.epochs_per_blob_prune == 1));
+}
+#[test]
+fn epochs_per_blob_prune_on_startup_five() {
+    CommandLineTest::new()
+        .flag("epochs-per-blob-prune", Some(5))
+        .run_with_zero_port()
+        .with_config(|config| assert!(!config.epochs_per_blob_prune == 5));
+}
+#[test]
+fn blob_prune_margin_epochs_default() {
+    CommandLineTest::new()
+        .run_with_zero_port()
+        .with_config(|config| assert!(config.blob_prune_margin_epochs == 0));
+}
+#[test]
+fn blob_prune_margin_epochs_on_startup_ten() {
+    CommandLineTest::new()
+        .flag("blob-prune-margin-epochs", Some(10))
+        .run_with_zero_port()
+        .with_config(|config| assert!(!config.blob_prune_margin_epochs == Some(10)));
+}
+#[test]
 fn reconstruct_historic_states_flag() {
     CommandLineTest::new()
         .flag("reconstruct-historic-states", None)