diff --git a/beacon_node/eth2_libp2p/src/peer_manager/mod.rs b/beacon_node/eth2_libp2p/src/peer_manager/mod.rs
index ae318e915..448768983 100644
--- a/beacon_node/eth2_libp2p/src/peer_manager/mod.rs
+++ b/beacon_node/eth2_libp2p/src/peer_manager/mod.rs
@@ -412,6 +412,12 @@ impl<TSpec: EthSpec> PeerManager<TSpec> {
             }
             RPCError::ErrorResponse(code, _) => match code {
                 RPCResponseErrorCode::Unknown => PeerAction::HighToleranceError,
+                RPCResponseErrorCode::ResourceUnavailable => {
+                    // NOTE: This error only makes sense for the `BlocksByRange` and `BlocksByRoot`
+                    // protocols. For the time being, there is no reason why a peer should send
+                    // this error.
+                    PeerAction::Fatal
+                }
                 RPCResponseErrorCode::ServerError => PeerAction::MidToleranceError,
                 RPCResponseErrorCode::InvalidRequest => PeerAction::LowToleranceError,
                 RPCResponseErrorCode::RateLimited => match protocol {
diff --git a/beacon_node/eth2_libp2p/src/rpc/methods.rs b/beacon_node/eth2_libp2p/src/rpc/methods.rs
index 3c8604387..b347f61f1 100644
--- a/beacon_node/eth2_libp2p/src/rpc/methods.rs
+++ b/beacon_node/eth2_libp2p/src/rpc/methods.rs
@@ -262,6 +262,8 @@ pub enum RPCResponseErrorCode {
     RateLimited,
     InvalidRequest,
     ServerError,
+    /// Error spec'd to indicate that a peer does not have blocks on a requested range.
+    ResourceUnavailable,
     Unknown,
 }
 
@@ -285,6 +287,7 @@ impl<T: EthSpec> RPCCodedResponse<T> {
         let code = match response_code {
             1 => RPCResponseErrorCode::InvalidRequest,
             2 => RPCResponseErrorCode::ServerError,
+            3 => RPCResponseErrorCode::ResourceUnavailable,
             139 => RPCResponseErrorCode::RateLimited,
             _ => RPCResponseErrorCode::Unknown,
         };
@@ -318,6 +321,7 @@ impl RPCResponseErrorCode {
         match self {
             RPCResponseErrorCode::InvalidRequest => 1,
             RPCResponseErrorCode::ServerError => 2,
+            RPCResponseErrorCode::ResourceUnavailable => 3,
             RPCResponseErrorCode::Unknown => 255,
             RPCResponseErrorCode::RateLimited => 139,
         }
@@ -328,6 +332,7 @@ impl std::fmt::Display for RPCResponseErrorCode {
     fn fmt(&self, f: &mut std::fmt::Formatter<'_>) -> std::fmt::Result {
         let repr = match self {
             RPCResponseErrorCode::InvalidRequest => "The request was invalid",
+            RPCResponseErrorCode::ResourceUnavailable => "Resource unavailable",
             RPCResponseErrorCode::ServerError => "Server error occurred",
             RPCResponseErrorCode::Unknown => "Unknown error occurred",
             RPCResponseErrorCode::RateLimited => "Rate limited",
diff --git a/beacon_node/eth2_libp2p/src/rpc/protocol.rs b/beacon_node/eth2_libp2p/src/rpc/protocol.rs
index 4af31f420..4cd01c59f 100644
--- a/beacon_node/eth2_libp2p/src/rpc/protocol.rs
+++ b/beacon_node/eth2_libp2p/src/rpc/protocol.rs
@@ -577,6 +577,7 @@ impl RPCError {
                 RPCResponseErrorCode::RateLimited => "rate_limited",
                 RPCResponseErrorCode::InvalidRequest => "invalid_request",
                 RPCResponseErrorCode::ServerError => "server_error",
+                RPCResponseErrorCode::ResourceUnavailable => "resource_unavailable",
                 RPCResponseErrorCode::Unknown => "unknown_response_code",
             },
             RPCError::StreamTimeout => "stream_timeout",