diff --git a/.circleci/config.yml b/.circleci/config.yml
index 3243d286..cd000563 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -146,8 +146,8 @@ jobs:
           environment:
             LAUNCHPAD_ENABLED: 1
             ERC20_ENABLED: 1
-            SIMAPP_ENABLED: 1
-            SLOW_SIMAPP_ENABLED: 1
+            SIMAPP42_ENABLED: 1
+            SLOW_SIMAPP42_ENABLED: 1
             TENDERMINT_ENABLED: 1
             SOCKETSERVER_ENABLED: 1
             SKIP_BUILD: 1
@@ -266,8 +266,8 @@ jobs:
           environment:
             LAUNCHPAD_ENABLED: 1
             ERC20_ENABLED: 1
-            SIMAPP_ENABLED: 1
-            SLOW_SIMAPP_ENABLED: 1
+            SIMAPP42_ENABLED: 1
+            SLOW_SIMAPP42_ENABLED: 1
             TENDERMINT_ENABLED: 1
             SOCKETSERVER_ENABLED: 1
             SKIP_BUILD: 1
@@ -382,8 +382,8 @@ jobs:
           environment:
             LAUNCHPAD_ENABLED: 1
             ERC20_ENABLED: 1
-            SIMAPP_ENABLED: 1
-            SLOW_SIMAPP_ENABLED: 1
+            SIMAPP42_ENABLED: 1
+            SLOW_SIMAPP42_ENABLED: 1
             TENDERMINT_ENABLED: 1
             SOCKETSERVER_ENABLED: 1
             SKIP_BUILD: 1
@@ -484,8 +484,8 @@ jobs:
           environment:
             LAUNCHPAD_ENABLED: 1
             ERC20_ENABLED: 1
-            SIMAPP_ENABLED: 1
-            SLOW_SIMAPP_ENABLED: 1
+            SIMAPP42_ENABLED: 1
+            SLOW_SIMAPP42_ENABLED: 1
             TENDERMINT_ENABLED: 1
             SOCKETSERVER_ENABLED: 1
             SKIP_BUILD: 1
diff --git a/packages/cli/run_examples.sh b/packages/cli/run_examples.sh
index ae5ba58c..b5a60f94 100755
--- a/packages/cli/run_examples.sh
+++ b/packages/cli/run_examples.sh
@@ -2,7 +2,7 @@
 set -o errexit -o nounset -o pipefail
 command -v shellcheck >/dev/null && shellcheck "$0"
 
-if [ -n "${SIMAPP_ENABLED:-}" ]; then
+if [ -n "${SIMAPP42_ENABLED:-}" ]; then
   yarn node ./bin/cosmwasm-cli --init examples/cosmwasm.ts --code "process.exit(0)"
 fi
 if [ -n "${LAUNCHPAD_ENABLED:-}" ]; then
@@ -13,6 +13,6 @@ yarn node ./bin/cosmwasm-cli --init examples/generate_address.ts --code "process
 yarn node ./bin/cosmwasm-cli --init examples/local_faucet.ts --code "process.exit(0)"
 yarn node ./bin/cosmwasm-cli --init examples/mask.ts --code "process.exit(0)"
 yarn node ./bin/cosmwasm-cli --init examples/multisig_address.ts --code "process.exit(0)"
-if [ -n "${SIMAPP_ENABLED:-}" ]; then
+if [ -n "${SIMAPP42_ENABLED:-}" ]; then
   yarn node ./bin/cosmwasm-cli --init examples/stargate.ts --code "process.exit(0)"
 fi
diff --git a/packages/faucet/src/faucet.spec.ts b/packages/faucet/src/faucet.spec.ts
index 13115347..21b42b2f 100644
--- a/packages/faucet/src/faucet.spec.ts
+++ b/packages/faucet/src/faucet.spec.ts
@@ -14,8 +14,8 @@ function pendingWithoutLaunchpad(): void {
 }
 
 function pendingWithoutSimapp(): void {
-  if (!process.env.SIMAPP_ENABLED) {
-    return pending("Set SIMAPP_ENABLED to enabled Stargate node-based tests");
+  if (!process.env.SIMAPP42_ENABLED && !process.env.SIMAPP44_ENABLED) {
+    return pending("Set SIMAPP42_ENABLED or SIMAPP44_ENABLED to enabled Stargate node-based tests");
   }
 }
 
diff --git a/packages/ledger-amino/README.md b/packages/ledger-amino/README.md
index 5abdf3d4..8660351e 100644
--- a/packages/ledger-amino/README.md
+++ b/packages/ledger-amino/README.md
@@ -63,7 +63,7 @@ and execute:
 
 ```sh
 export LEDGER_ENABLED=1
-export SIMAPP_ENABLED=1
+export SIMAPP42_ENABLED=1
 yarn test
 ```
 
diff --git a/packages/ledger-amino/src/testutils.spec.ts b/packages/ledger-amino/src/testutils.spec.ts
index 32b61512..ce2d9151 100644
--- a/packages/ledger-amino/src/testutils.spec.ts
+++ b/packages/ledger-amino/src/testutils.spec.ts
@@ -29,12 +29,12 @@ export function pendingWithoutLaunchpad(): void {
 }
 
 export function simappEnabled(): boolean {
-  return !!process.env.SIMAPP_ENABLED;
+  return !!process.env.SIMAPP42_ENABLED || !!process.env.SIMAPP44_ENABLED;
 }
 
 export function pendingWithoutSimapp(): void {
   if (!simappEnabled()) {
-    return pending("Set SIMAPP_ENABLED to enable Simapp-based tests");
+    return pending("Set SIMAPP42_ENABLED or SIMAPP44_ENABLED to enable Simapp-based tests");
   }
 }
 
diff --git a/packages/stargate/src/queries/ibc.spec.ts b/packages/stargate/src/queries/ibc.spec.ts
index 3cbd832b..5d425f6a 100644
--- a/packages/stargate/src/queries/ibc.spec.ts
+++ b/packages/stargate/src/queries/ibc.spec.ts
@@ -1,7 +1,7 @@
 import { Tendermint34Client } from "@cosmjs/tendermint-rpc";
 import Long from "long";
 
-import { pendingWithoutSimapp, simapp } from "../testutils.spec";
+import { pendingWithoutSimapp42, simapp } from "../testutils.spec";
 import { IbcExtension, setupIbcExtension } from "./ibc";
 import * as ibcTest from "./ibctestdata.spec";
 import { QueryClient } from "./queryclient";
@@ -15,7 +15,7 @@ describe("IbcExtension", () => {
   describe("channel", () => {
     describe("channel", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.channel(ibcTest.portId, ibcTest.channelId);
@@ -29,7 +29,7 @@ describe("IbcExtension", () => {
 
     describe("channels", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.channels();
@@ -43,7 +43,7 @@ describe("IbcExtension", () => {
 
     describe("allChannels", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.allChannels();
@@ -55,7 +55,7 @@ describe("IbcExtension", () => {
 
     describe("connectionChannels", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.connectionChannels(ibcTest.connectionId);
@@ -69,7 +69,7 @@ describe("IbcExtension", () => {
 
     describe("allConnectionChannels", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.allConnectionChannels(ibcTest.connectionId);
@@ -81,7 +81,7 @@ describe("IbcExtension", () => {
 
     describe("clientState", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.clientState(ibcTest.portId, ibcTest.channelId);
@@ -99,7 +99,7 @@ describe("IbcExtension", () => {
 
     describe("consensusState", () => {
       xit("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.consensusState(
@@ -121,7 +121,7 @@ describe("IbcExtension", () => {
 
     describe("packetCommitment", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.packetCommitment(
@@ -139,7 +139,7 @@ describe("IbcExtension", () => {
 
     describe("packetCommitments", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.packetCommitments(ibcTest.portId, ibcTest.channelId);
@@ -153,7 +153,7 @@ describe("IbcExtension", () => {
 
     describe("allPacketCommitments", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.allPacketCommitments(ibcTest.portId, ibcTest.channelId);
@@ -165,7 +165,7 @@ describe("IbcExtension", () => {
 
     describe("packetReceipt", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.packetReceipt(ibcTest.portId, ibcTest.channelId, 1);
@@ -178,7 +178,7 @@ describe("IbcExtension", () => {
     describe("packetAcknowledgement", () => {
       it("works", async () => {
         pending("We don't have an acknowledgement for testing at the moment");
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.packetAcknowledgement(
@@ -196,7 +196,7 @@ describe("IbcExtension", () => {
 
     describe("packetAcknowledgements", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.packetAcknowledgements(ibcTest.portId, ibcTest.channelId);
@@ -210,7 +210,7 @@ describe("IbcExtension", () => {
 
     describe("allPacketAcknowledgements", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.allPacketAcknowledgements(
@@ -225,7 +225,7 @@ describe("IbcExtension", () => {
 
     describe("unreceivedPackets", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.unreceivedPackets(
@@ -242,7 +242,7 @@ describe("IbcExtension", () => {
 
     describe("unreceivedAcks", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.unreceivedAcks(
@@ -259,7 +259,7 @@ describe("IbcExtension", () => {
 
     describe("nextSequenceReceive", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.channel.nextSequenceReceive(ibcTest.portId, ibcTest.channelId);
@@ -275,7 +275,7 @@ describe("IbcExtension", () => {
   describe("client", () => {
     describe("state", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.state(ibcTest.clientId);
@@ -290,7 +290,7 @@ describe("IbcExtension", () => {
 
     describe("states", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.states();
@@ -311,7 +311,7 @@ describe("IbcExtension", () => {
 
     describe("allStates", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.allStates();
@@ -331,7 +331,7 @@ describe("IbcExtension", () => {
 
     describe("consensusState", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.consensusState(ibcTest.clientId);
@@ -346,7 +346,7 @@ describe("IbcExtension", () => {
 
     describe("consensusStates", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.consensusStates(ibcTest.clientId);
@@ -368,7 +368,7 @@ describe("IbcExtension", () => {
 
     describe("allConsensusStates", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.allConsensusStates(ibcTest.clientId);
@@ -390,7 +390,7 @@ describe("IbcExtension", () => {
 
     describe("params", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.params();
@@ -404,7 +404,7 @@ describe("IbcExtension", () => {
 
     describe("stateTm", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.stateTm(ibcTest.clientId);
@@ -417,7 +417,7 @@ describe("IbcExtension", () => {
 
     describe("statesTm", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.statesTm();
@@ -435,7 +435,7 @@ describe("IbcExtension", () => {
 
     describe("allStatesTm", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.allStatesTm();
@@ -453,7 +453,7 @@ describe("IbcExtension", () => {
 
     describe("consensusStateTm", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.client.consensusStateTm(ibcTest.clientId);
@@ -468,7 +468,7 @@ describe("IbcExtension", () => {
   describe("connection", () => {
     describe("connection", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.connection.connection(ibcTest.connectionId);
@@ -482,7 +482,7 @@ describe("IbcExtension", () => {
 
     describe("connections", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.connection.connections();
@@ -496,7 +496,7 @@ describe("IbcExtension", () => {
 
     describe("allConnections", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.connection.allConnections();
@@ -508,7 +508,7 @@ describe("IbcExtension", () => {
 
     describe("clientConnections", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.connection.clientConnections(ibcTest.clientId);
@@ -522,7 +522,7 @@ describe("IbcExtension", () => {
 
     describe("clientState", () => {
       it("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         const response = await client.ibc.connection.clientState(ibcTest.connectionId);
@@ -540,7 +540,7 @@ describe("IbcExtension", () => {
 
     describe("consensusState", () => {
       xit("works", async () => {
-        pendingWithoutSimapp();
+        pendingWithoutSimapp42();
         const [client, tmClient] = await makeClientWithIbc(simapp.tendermintUrl);
 
         // TODO: Find valid values
diff --git a/packages/stargate/src/signingstargateclient.spec.ts b/packages/stargate/src/signingstargateclient.spec.ts
index 5488151a..8996a29f 100644
--- a/packages/stargate/src/signingstargateclient.spec.ts
+++ b/packages/stargate/src/signingstargateclient.spec.ts
@@ -23,6 +23,7 @@ import {
   ModifyingDirectSecp256k1HdWallet,
   ModifyingSecp256k1HdWallet,
   pendingWithoutSimapp,
+  pendingWithoutSimapp42,
   simapp,
   validator,
 } from "./testutils.spec";
@@ -117,7 +118,7 @@ describe("SigningStargateClient", () => {
 
   describe("sendIbcTokens", () => {
     it("works with direct signing", async () => {
-      pendingWithoutSimapp();
+      pendingWithoutSimapp42();
       const wallet = await DirectSecp256k1HdWallet.fromMnemonic(faucet.mnemonic);
       const client = await SigningStargateClient.connectWithSigner(
         simapp.tendermintUrl,
@@ -166,7 +167,7 @@ describe("SigningStargateClient", () => {
     });
 
     it("works with Amino signing", async () => {
-      pendingWithoutSimapp();
+      pendingWithoutSimapp42();
       const wallet = await Secp256k1HdWallet.fromMnemonic(faucet.mnemonic);
       const client = await SigningStargateClient.connectWithSigner(
         simapp.tendermintUrl,
diff --git a/packages/stargate/src/testutils.spec.ts b/packages/stargate/src/testutils.spec.ts
index a32c4e07..5970efbb 100644
--- a/packages/stargate/src/testutils.spec.ts
+++ b/packages/stargate/src/testutils.spec.ts
@@ -15,23 +15,37 @@ import { AuthInfo, SignDoc, TxBody } from "cosmjs-types/cosmos/tx/v1beta1/tx";
 import { calculateFee, GasPrice } from "./fee";
 import { SigningStargateClientOptions } from "./signingstargateclient";
 
+export function simapp42Enabled(): boolean {
+  return !!process.env.SIMAPP42_ENABLED;
+}
+
+export function simapp44Enabled(): boolean {
+  return !!process.env.SIMAPP44_ENABLED;
+}
+
 export function simappEnabled(): boolean {
-  return !!process.env.SIMAPP_ENABLED;
+  return simapp42Enabled() || simapp44Enabled();
+}
+
+export function pendingWithoutSimapp42(): void {
+  if (!simapp42Enabled()) {
+    return pending("Set SIMAPP44_ENABLED to enable Simapp based tests");
+  }
 }
 
 export function pendingWithoutSimapp(): void {
   if (!simappEnabled()) {
-    return pending("Set SIMAPP_ENABLED to enable Simapp based tests");
+    return pending("Set SIMAPP42_ENABLED or SIMAPP44_ENABLED to enable Simapp based tests");
   }
 }
 
 export function slowSimappEnabled(): boolean {
-  return !!process.env.SLOW_SIMAPP_ENABLED;
+  return !!process.env.SLOW_SIMAPP42_ENABLED || !!process.env.SLOW_SIMAPP44_ENABLED;
 }
 
 export function pendingWithoutSlowSimapp(): void {
   if (!slowSimappEnabled()) {
-    return pending("Set SLOW_SIMAPP_ENABLED to enable slow Simapp based tests");
+    return pending("Set SLOW_SIMAPP42_ENABLED or SLOW_SIMAPP44_ENABLED to enable slow Simapp based tests");
   }
 }
 
diff --git a/packages/stargate/webpack.web.config.js b/packages/stargate/webpack.web.config.js
index fc27f3e8..838675a0 100644
--- a/packages/stargate/webpack.web.config.js
+++ b/packages/stargate/webpack.web.config.js
@@ -16,7 +16,12 @@ module.exports = [
       filename: "tests.js",
     },
     plugins: [
-      new webpack.EnvironmentPlugin({ SIMAPP_ENABLED: "", SLOW_SIMAPP_ENABLED: "" }),
+      new webpack.EnvironmentPlugin({
+        SIMAPP42_ENABLED: "",
+        SLOW_SIMAPP42_ENABLED: "",
+        SIMAPP44_ENABLED: "",
+        SLOW_SIMAPP44_ENABLED: "",
+      }),
       new webpack.ProvidePlugin({
         Buffer: ["buffer", "Buffer"],
       }),