diff --git a/CHANGELOG.md b/CHANGELOG.md
index 90cf46dd..f0134e9b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,12 @@ and this project adheres to
 
 ## [Unreleased]
 
+### Added
+
+- @cosmjs/cosmwasm-stargate: Add `SigningCosmWasmClient.instantiate2` ([#1407]).
+
+[#1407]: https://github.com/cosmos/cosmjs/pull/1407
+
 ### Changed
 
 - all: upgrade cosmjs-types to 0.8.0 to include Cosmos SDK 0.46/0.47 and IBC v7
diff --git a/packages/cosmwasm-stargate/src/index.ts b/packages/cosmwasm-stargate/src/index.ts
index 91c5af34..602f8115 100644
--- a/packages/cosmwasm-stargate/src/index.ts
+++ b/packages/cosmwasm-stargate/src/index.ts
@@ -5,6 +5,7 @@ export {
   createWasmAminoConverters,
   isMsgClearAdminEncodeObject,
   isMsgExecuteEncodeObject,
+  isMsgInstantiateContract2EncodeObject,
   isMsgInstantiateContractEncodeObject,
   isMsgMigrateEncodeObject,
   isMsgStoreCodeEncodeObject,
@@ -12,6 +13,7 @@ export {
   JsonObject,
   MsgClearAdminEncodeObject,
   MsgExecuteContractEncodeObject,
+  MsgInstantiateContract2EncodeObject,
   MsgInstantiateContractEncodeObject,
   MsgMigrateContractEncodeObject,
   MsgStoreCodeEncodeObject,
diff --git a/packages/cosmwasm-stargate/src/modules/index.ts b/packages/cosmwasm-stargate/src/modules/index.ts
index 04cb2a79..2b3114cb 100644
--- a/packages/cosmwasm-stargate/src/modules/index.ts
+++ b/packages/cosmwasm-stargate/src/modules/index.ts
@@ -10,12 +10,14 @@ export {
 export {
   isMsgClearAdminEncodeObject,
   isMsgExecuteEncodeObject,
+  isMsgInstantiateContract2EncodeObject,
   isMsgInstantiateContractEncodeObject,
   isMsgMigrateEncodeObject,
   isMsgStoreCodeEncodeObject,
   isMsgUpdateAdminEncodeObject,
   MsgClearAdminEncodeObject,
   MsgExecuteContractEncodeObject,
+  MsgInstantiateContract2EncodeObject,
   MsgInstantiateContractEncodeObject,
   MsgMigrateContractEncodeObject,
   MsgStoreCodeEncodeObject,
diff --git a/packages/cosmwasm-stargate/src/modules/wasm/messages.ts b/packages/cosmwasm-stargate/src/modules/wasm/messages.ts
index e9a1ea02..bf3fc00c 100644
--- a/packages/cosmwasm-stargate/src/modules/wasm/messages.ts
+++ b/packages/cosmwasm-stargate/src/modules/wasm/messages.ts
@@ -3,6 +3,7 @@ import {
   MsgClearAdmin,
   MsgExecuteContract,
   MsgInstantiateContract,
+  MsgInstantiateContract2,
   MsgMigrateContract,
   MsgStoreCode,
   MsgUpdateAdmin,
@@ -14,6 +15,7 @@ export const wasmTypes: ReadonlyArray<[string, GeneratedType]> = [
   ["/cosmwasm.wasm.v1.MsgMigrateContract", MsgMigrateContract],
   ["/cosmwasm.wasm.v1.MsgStoreCode", MsgStoreCode],
   ["/cosmwasm.wasm.v1.MsgInstantiateContract", MsgInstantiateContract],
+  ["/cosmwasm.wasm.v1.MsgInstantiateContract2", MsgInstantiateContract2],
   ["/cosmwasm.wasm.v1.MsgUpdateAdmin", MsgUpdateAdmin],
 ];
 
@@ -39,6 +41,19 @@ export function isMsgInstantiateContractEncodeObject(
   );
 }
 
+export interface MsgInstantiateContract2EncodeObject extends EncodeObject {
+  readonly typeUrl: "/cosmwasm.wasm.v1.MsgInstantiateContract2";
+  readonly value: Partial<MsgInstantiateContract2>;
+}
+
+export function isMsgInstantiateContract2EncodeObject(
+  object: EncodeObject,
+): object is MsgInstantiateContract2EncodeObject {
+  return (
+    (object as MsgInstantiateContract2EncodeObject).typeUrl === "/cosmwasm.wasm.v1.MsgInstantiateContract2"
+  );
+}
+
 export interface MsgUpdateAdminEncodeObject extends EncodeObject {
   readonly typeUrl: "/cosmwasm.wasm.v1.MsgUpdateAdmin";
   readonly value: Partial<MsgUpdateAdmin>;
diff --git a/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts b/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts
index 22ae12b0..11f49958 100644
--- a/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts
+++ b/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts
@@ -24,6 +24,7 @@ import Long from "long";
 import pako from "pako";
 import protobuf from "protobufjs/minimal";
 
+import { instantiate2Address } from "./instantiate2";
 import { MsgExecuteContractEncodeObject, MsgStoreCodeEncodeObject } from "./modules";
 import { SigningCosmWasmClient } from "./signingcosmwasmclient";
 import {
@@ -252,6 +253,50 @@ describe("SigningCosmWasmClient", () => {
     });
   });
 
+  describe("instantiate2", () => {
+    it("can instantiate with predictable address", async () => {
+      pendingWithoutWasmd();
+      const wallet = await DirectSecp256k1HdWallet.fromMnemonic(alice.mnemonic, {
+        prefix: wasmd.prefix,
+      });
+      const options = { ...defaultSigningClientOptions, prefix: wasmd.prefix };
+
+      const client = await SigningCosmWasmClient.connectWithSigner(wasmd.endpoint, wallet, options);
+      const { codeId } = await client.upload(alice.address0, getHackatom().data, defaultUploadFee);
+      const funds = [coin(1234, "ucosm"), coin(321, "ustake")];
+      const beneficiaryAddress = makeRandomAddress();
+      const salt = Uint8Array.from([0x01]);
+      const wasm = getHackatom().data;
+      const msg = {
+        verifier: alice.address0,
+        beneficiary: beneficiaryAddress,
+      };
+      const expectedAddress = instantiate2Address(sha256(wasm), alice.address0, salt, wasmd.prefix);
+
+      const { contractAddress } = await client.instantiate2(
+        alice.address0,
+        codeId,
+        salt,
+        msg,
+        "My cool label--",
+        defaultInstantiateFee,
+        {
+          memo: "Let's see if the memo is used",
+          funds: funds,
+        },
+      );
+
+      const wasmClient = await makeWasmClient(wasmd.endpoint);
+      const ucosmBalance = await wasmClient.bank.balance(contractAddress, "ucosm");
+      const ustakeBalance = await wasmClient.bank.balance(contractAddress, "ustake");
+      expect(ucosmBalance).toEqual(funds[0]);
+      expect(ustakeBalance).toEqual(funds[1]);
+
+      expect(contractAddress).toEqual(expectedAddress);
+      client.disconnect();
+    });
+  });
+
   describe("updateAdmin", () => {
     it("can update an admin", async () => {
       pendingWithoutWasmd();
diff --git a/packages/cosmwasm-stargate/src/signingcosmwasmclient.ts b/packages/cosmwasm-stargate/src/signingcosmwasmclient.ts
index 0373ac3a..b3c15aca 100644
--- a/packages/cosmwasm-stargate/src/signingcosmwasmclient.ts
+++ b/packages/cosmwasm-stargate/src/signingcosmwasmclient.ts
@@ -46,6 +46,7 @@ import {
   MsgClearAdmin,
   MsgExecuteContract,
   MsgInstantiateContract,
+  MsgInstantiateContract2,
   MsgMigrateContract,
   MsgStoreCode,
   MsgUpdateAdmin,
@@ -59,6 +60,7 @@ import {
   JsonObject,
   MsgClearAdminEncodeObject,
   MsgExecuteContractEncodeObject,
+  MsgInstantiateContract2EncodeObject,
   MsgInstantiateContractEncodeObject,
   MsgMigrateContractEncodeObject,
   MsgStoreCodeEncodeObject,
@@ -86,7 +88,7 @@ export interface UploadResult {
 }
 
 /**
- * The options of an .instantiate() call.
+ * The options of .instantiate() and .instantiate2() call.
  * All properties are optional.
  */
 export interface InstantiateOptions {
@@ -348,6 +350,45 @@ export class SigningCosmWasmClient extends CosmWasmClient {
     };
   }
 
+  public async instantiate2(
+    senderAddress: string,
+    codeId: number,
+    salt: Uint8Array,
+    msg: JsonObject,
+    label: string,
+    fee: StdFee | "auto" | number,
+    options: InstantiateOptions = {},
+  ): Promise<InstantiateResult> {
+    const instantiateContract2Msg: MsgInstantiateContract2EncodeObject = {
+      typeUrl: "/cosmwasm.wasm.v1.MsgInstantiateContract2",
+      value: MsgInstantiateContract2.fromPartial({
+        sender: senderAddress,
+        codeId: Long.fromString(new Uint53(codeId).toString()),
+        label: label,
+        msg: toUtf8(JSON.stringify(msg)),
+        funds: [...(options.funds || [])],
+        admin: options.admin,
+        salt: salt,
+        fixMsg: false,
+      }),
+    };
+    const result = await this.signAndBroadcast(senderAddress, [instantiateContract2Msg], fee, options.memo);
+    if (isDeliverTxFailure(result)) {
+      throw new Error(createDeliverTxResponseErrorMessage(result));
+    }
+    const parsedLogs = logs.parseRawLog(result.rawLog);
+    const contractAddressAttr = logs.findAttribute(parsedLogs, "instantiate", "_contract_address");
+    return {
+      contractAddress: contractAddressAttr.value,
+      logs: parsedLogs,
+      height: result.height,
+      transactionHash: result.transactionHash,
+      events: result.events,
+      gasWanted: result.gasWanted,
+      gasUsed: result.gasUsed,
+    };
+  }
+
   public async updateAdmin(
     senderAddress: string,
     contractAddress: string,